Prevalence of ataxia in children: A systematic review

Kristin E. Musselman, Cristina T. Stoyanov, Rhul Marasigan, Mary E. Jenkins, Jürgen Konczak, Susanne M. Morton, Amy J. Bastian

Research output: Contribution to journalReview article

Abstract

Objective: To estimate the prevalence of childhood ataxia resulting from both genetic and acquired causes. Methods: A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Five databases were searched for articles reporting a frequency measure (e.g., prevalence, incidence) of ataxia in children. Included articles were first grouped according to the World Health Organization (WHO) regions and subsequently classified according to etiology (genetic, acquired, or mixed). Each article was assessed for its risk of bias on the domains of sampling, measurement, and analysis. Incidence values were converted to prevalence estimates whenever possible. European prevalence estimates for different etiologies of ataxia were summed to gauge the overall prevalence of childhood ataxia. Results: One hundred fifteen articles were included in the review. More than 50% of the data originated from the Europe WHO region. Data from this region also showed the least susceptibility to bias. Little data were available for Africa and Southeast Asia. The prevalence of acquired ataxias was found to vary more greatly across regions than the genetic ataxias. Ataxic cerebral palsy was found to be a significant contributor to the overall prevalence of childhood ataxia across WHO regions. The prevalence of childhood ataxias in Europe was estimated to be ~26/100,000 children and likely reflects a minimum prevalence worldwide. Conclusions: The findings show that ataxia is a common childhood motor disorder with a higher prevalence than previously assumed. More research concerning the epidemiology, assessment, and treatment of childhood ataxia is warranted.

Original languageEnglish (US)
Pages (from-to)80-89
Number of pages10
JournalNeurology
Volume82
Issue number1
DOIs
StatePublished - Jan 7 2014

ASJC Scopus subject areas

  • Clinical Neurology

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    Musselman, K. E., Stoyanov, C. T., Marasigan, R., Jenkins, M. E., Konczak, J., Morton, S. M., & Bastian, A. J. (2014). Prevalence of ataxia in children: A systematic review. Neurology, 82(1), 80-89. https://doi.org/10.1212/01.wnl.0000438224.25600.6c