Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F. Brun-Vézinet, C. Rouzioux, L. Montagnier, S. Chamaret, J. Gruest, F. Barré-Sinoussi, D. Geroldi, J. C. Chermann, J. Mccormick, S. Mitchell, P. Piot, H. Taelman, Kapita Bila Mirlangu, Odio Wobin, N. Mbendi, P. Mazebo, Kayembe Kalambayi, C. Bridts, J. Desmyter, F. M. FeinsodT. C. Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.

Original languageEnglish (US)
Pages (from-to)453-456
Number of pages4
JournalScience
Volume226
Issue number4673
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • General

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