Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F. Brun-Vézinet, C. Rouzioux, L. Montagnier, S. Chamaret, J. Gruest, F. Barré-Sinoussi, D. Geroldi, J. C. Chermann, J. Mccormick, S. Mitchell, P. Piot, H. Taelman, Kapita Bila Mirlangu, Odio Wobin, N. Mbendi, P. Mazebo, Kayembe Kalambayi, C. Bridts, J. Desmyter, F. M. FeinsodThomas C Quinn

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Abstract

The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.

Original languageEnglish (US)
Pages (from-to)453-456
Number of pages4
JournalScience
Volume226
Issue number4673
StatePublished - 1984
Externally publishedYes

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HIV Antibodies
Retroviridae
Acquired Immunodeficiency Syndrome
Radioimmunoprecipitation Assay
CD8-Positive T-Lymphocytes
Democratic Republic of the Congo
Control Groups
Serum
Communicable Diseases
Enzyme-Linked Immunosorbent Assay
Mothers

ASJC Scopus subject areas

  • General

Cite this

Brun-Vézinet, F., Rouzioux, C., Montagnier, L., Chamaret, S., Gruest, J., Barré-Sinoussi, F., ... Quinn, T. C. (1984). Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS. Science, 226(4673), 453-456.

Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS. / Brun-Vézinet, F.; Rouzioux, C.; Montagnier, L.; Chamaret, S.; Gruest, J.; Barré-Sinoussi, F.; Geroldi, D.; Chermann, J. C.; Mccormick, J.; Mitchell, S.; Piot, P.; Taelman, H.; Mirlangu, Kapita Bila; Wobin, Odio; Mbendi, N.; Mazebo, P.; Kalambayi, Kayembe; Bridts, C.; Desmyter, J.; Feinsod, F. M.; Quinn, Thomas C.

In: Science, Vol. 226, No. 4673, 1984, p. 453-456.

Research output: Contribution to journalArticle

Brun-Vézinet, F, Rouzioux, C, Montagnier, L, Chamaret, S, Gruest, J, Barré-Sinoussi, F, Geroldi, D, Chermann, JC, Mccormick, J, Mitchell, S, Piot, P, Taelman, H, Mirlangu, KB, Wobin, O, Mbendi, N, Mazebo, P, Kalambayi, K, Bridts, C, Desmyter, J, Feinsod, FM & Quinn, TC 1984, 'Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS', Science, vol. 226, no. 4673, pp. 453-456.
Brun-Vézinet F, Rouzioux C, Montagnier L, Chamaret S, Gruest J, Barré-Sinoussi F et al. Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS. Science. 1984;226(4673):453-456.
Brun-Vézinet, F. ; Rouzioux, C. ; Montagnier, L. ; Chamaret, S. ; Gruest, J. ; Barré-Sinoussi, F. ; Geroldi, D. ; Chermann, J. C. ; Mccormick, J. ; Mitchell, S. ; Piot, P. ; Taelman, H. ; Mirlangu, Kapita Bila ; Wobin, Odio ; Mbendi, N. ; Mazebo, P. ; Kalambayi, Kayembe ; Bridts, C. ; Desmyter, J. ; Feinsod, F. M. ; Quinn, Thomas C. / Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS. In: Science. 1984 ; Vol. 226, No. 4673. pp. 453-456.
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abstract = "The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.",
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AU - Rouzioux, C.

AU - Montagnier, L.

AU - Chamaret, S.

AU - Gruest, J.

AU - Barré-Sinoussi, F.

AU - Geroldi, D.

AU - Chermann, J. C.

AU - Mccormick, J.

AU - Mitchell, S.

AU - Piot, P.

AU - Taelman, H.

AU - Mirlangu, Kapita Bila

AU - Wobin, Odio

AU - Mbendi, N.

AU - Mazebo, P.

AU - Kalambayi, Kayembe

AU - Bridts, C.

AU - Desmyter, J.

AU - Feinsod, F. M.

AU - Quinn, Thomas C

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