Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American populations

Elizabeth D. Ferucci, Erika Darrah, Irene Smolik, Tammy L. Choromanski, David B. Robinson, Marianna M. Newkirk, Marvin J. Fritzler, Antony Rosen, Hani S. El-Gabalawy

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To determine whether anti-peptidylarginine deiminase type 4 (PAD4) antibodies were present in first-degree relatives (FDR) of patients with rheumatoid arthritis (RA) in 2 indigenous North American populations with high prevalence of RA. Methods. Participants were recruited from 2 indigenous populations in Canada and the United States, including patients with RA (probands), their unaffected FDR, and healthy unrelated controls. Sera were tested for the presence of anti-PAD4 antibodies, anticyclic citrullinated peptide (anti-CCP) antibodies, and rheumatoid factor (RF). HLA-DRB1 subtyping was performed and participants were classified according to number of shared-epitope alleles present. Results. Antibodies to PAD4 were detected in 24 of 82 (29.3%) probands; 2 of 147 (1.4%) relatives; and no controls (p < 0.0001). Anti-CCP was present in 39/144 (27.1%) of the relatives, and there was no overlap between positivity for anti-CCP and PAD4 in the relatives. In RA patients, anti-PAD4 antibodies were associated with disease duration (p = 0.0082) and anti-CCP antibodies (p = 0.008), but not smoking or shared-epitope alleles. Conclusion. Despite a significant prevalence of anti-CCP in FDR, anti-PAD4 antibodies were almost exclusively found in established RA. The prevalence of anti-PAD4 antibodies in RA is similar to the prevalence described in other populations and these autoantibodies are associated with disease duration and anti-CCP in RA. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)1523-1528
Number of pages6
JournalJournal of Rheumatology
Volume40
Issue number9
DOIs
StatePublished - Sep 2013

Keywords

  • Arthritis
  • Autoantibodies
  • Peptidylarginine deiminase
  • Rheumatoid

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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