Prevalence of and risk factors for diabetic macular edema in the United States

Rohit Varma, Neil M Bressler, Quan V. Doan, Michelle Gleeson, Mark Danese, Julie K. Bower, Elizabeth Selvin, Chantal Dolan, Jennifer Fine, Shoshana Colman, Adam Turpcu

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: Diabetic macular edema (DME) is a leading cause of vision loss in persons with diabetes mellitus. Although there are national estimates for the prevalence of diabetic retinopathy and its risk factors among persons with diabetes, to our knowledge, no comparable estimates are available for DME specifically. OBJECTIVES: To estimate the prevalence of DME in the US population and to identify associated risk factors. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional analysis of 1038 participants aged 40 years or older with diabetes and valid fundus photographs in the 2005 to 2008 National Health and Nutrition Examination Survey. MAIN OUTCOMES AND MEASURES: The overall prevalence of DME and its prevalence according to age, race/ethnicity, and sex. RESULTS: Of the 1038 persons with diabetes analyzed for this study, 55 had DME, for an overall weighted prevalence of 3.8% (95%CI, 2.7%-4.9%) or approximately 746 000 persons in the US 2010 population aged 40 years or older. We identified no differences in the prevalence of DME by age or sex. Multivariable logistic regression analysis showed that the odds of having DME were higher for non-Hispanic blacks than for non-Hispanic whites (odds ratio [OR], 2.64; 95%CI, 1.19-5.84; P = .02). Elevated levels of glycosylated hemoglobin A1c (OR, 1.47; 95%CI, 1.26-1.71 for each 1%; P <.001) and longer duration of diabetes (OR, 8.51; 95%CI, 3.70-19.54 for ≥10 vs

Original languageEnglish (US)
Pages (from-to)1334-1340
Number of pages7
JournalJAMA Ophthalmology
Volume132
Issue number11
DOIs
StatePublished - Nov 1 2014

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Macular Edema
Odds Ratio
Nutrition Surveys
Glycosylated Hemoglobin A
Diabetic Retinopathy
Population
Diabetes Mellitus
Cross-Sectional Studies
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

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Varma, R., Bressler, N. M., Doan, Q. V., Gleeson, M., Danese, M., Bower, J. K., ... Turpcu, A. (2014). Prevalence of and risk factors for diabetic macular edema in the United States. JAMA Ophthalmology, 132(11), 1334-1340. https://doi.org/10.1001/jamaophthalmol.2014.2854

Prevalence of and risk factors for diabetic macular edema in the United States. / Varma, Rohit; Bressler, Neil M; Doan, Quan V.; Gleeson, Michelle; Danese, Mark; Bower, Julie K.; Selvin, Elizabeth; Dolan, Chantal; Fine, Jennifer; Colman, Shoshana; Turpcu, Adam.

In: JAMA Ophthalmology, Vol. 132, No. 11, 01.11.2014, p. 1334-1340.

Research output: Contribution to journalArticle

Varma, R, Bressler, NM, Doan, QV, Gleeson, M, Danese, M, Bower, JK, Selvin, E, Dolan, C, Fine, J, Colman, S & Turpcu, A 2014, 'Prevalence of and risk factors for diabetic macular edema in the United States', JAMA Ophthalmology, vol. 132, no. 11, pp. 1334-1340. https://doi.org/10.1001/jamaophthalmol.2014.2854
Varma, Rohit ; Bressler, Neil M ; Doan, Quan V. ; Gleeson, Michelle ; Danese, Mark ; Bower, Julie K. ; Selvin, Elizabeth ; Dolan, Chantal ; Fine, Jennifer ; Colman, Shoshana ; Turpcu, Adam. / Prevalence of and risk factors for diabetic macular edema in the United States. In: JAMA Ophthalmology. 2014 ; Vol. 132, No. 11. pp. 1334-1340.
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abstract = "IMPORTANCE: Diabetic macular edema (DME) is a leading cause of vision loss in persons with diabetes mellitus. Although there are national estimates for the prevalence of diabetic retinopathy and its risk factors among persons with diabetes, to our knowledge, no comparable estimates are available for DME specifically. OBJECTIVES: To estimate the prevalence of DME in the US population and to identify associated risk factors. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional analysis of 1038 participants aged 40 years or older with diabetes and valid fundus photographs in the 2005 to 2008 National Health and Nutrition Examination Survey. MAIN OUTCOMES AND MEASURES: The overall prevalence of DME and its prevalence according to age, race/ethnicity, and sex. RESULTS: Of the 1038 persons with diabetes analyzed for this study, 55 had DME, for an overall weighted prevalence of 3.8{\%} (95{\%}CI, 2.7{\%}-4.9{\%}) or approximately 746 000 persons in the US 2010 population aged 40 years or older. We identified no differences in the prevalence of DME by age or sex. Multivariable logistic regression analysis showed that the odds of having DME were higher for non-Hispanic blacks than for non-Hispanic whites (odds ratio [OR], 2.64; 95{\%}CI, 1.19-5.84; P = .02). Elevated levels of glycosylated hemoglobin A1c (OR, 1.47; 95{\%}CI, 1.26-1.71 for each 1{\%}; P <.001) and longer duration of diabetes (OR, 8.51; 95{\%}CI, 3.70-19.54 for ≥10 vs",
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