Prevalence of Alzheimer’s Disease in a Community Population of Older Persons: Higher Than Previously Reported

Denis A. Evans, H. Harris Funkenstein, Marilyn Albert, Paul A. Scherr, Nancy R. Cook, Marilyn J. Chown, Liesi E. Hebert, Charles H. Hennekens, James O. Taylor

Research output: Contribution to journalArticle

Abstract

Clinically diagnosed Alzheimer’s disease and other dementing illnesses were assessed in a geographically defined US community. Of 3623 persons (80.8% of all community residents over 65 years of age) who had brief memory testing in their homes, a stratified sample of 467 persons underwent neurological, neuropsychological, and laboratory examination. Prevalence rates of Alzheimer’s disease were calculated for the community population from the sample undergoing clinical evaluation. Of those over the age of 65 years, an estimated 10.3% (95% confidence limits, 8.1% and 12.5%) had probable Alzheimer’s disease. This prevalence rate was strongly associated with age. Of those 65 to 74 years old, 3.0% (95% confidence limits, 0.8 and 5.2) had probable Alzheimer’s disease, compared with 18.7% (95% confidence limits, 13.2 and 24.2) of those 75 to 84 years old and 47.2% (95% confidence limits, 37.0 and 63.2) of those over 85 years. Other dementing conditions were uncommon. Of community residents with moderate or severe cognitive impairment, 84.1% had clinically diagnosed Alzheimer’s disease as the only probable diagnosis. These data suggest that clinically diagnosed Alzheimer’s disease is a common condition and that its public health impact will continue to increase with increasing longevity of the population.

Original languageEnglish (US)
Pages (from-to)2551-2556
Number of pages6
JournalJournal of the American Medical Association
Volume262
Issue number18
DOIs
StatePublished - Nov 10 1989
Externally publishedYes

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Alzheimer Disease
Population
Public Health

ASJC Scopus subject areas

  • Medicine(all)

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Prevalence of Alzheimer’s Disease in a Community Population of Older Persons : Higher Than Previously Reported. / Evans, Denis A.; Funkenstein, H. Harris; Albert, Marilyn; Scherr, Paul A.; Cook, Nancy R.; Chown, Marilyn J.; Hebert, Liesi E.; Hennekens, Charles H.; Taylor, James O.

In: Journal of the American Medical Association, Vol. 262, No. 18, 10.11.1989, p. 2551-2556.

Research output: Contribution to journalArticle

Evans, DA, Funkenstein, HH, Albert, M, Scherr, PA, Cook, NR, Chown, MJ, Hebert, LE, Hennekens, CH & Taylor, JO 1989, 'Prevalence of Alzheimer’s Disease in a Community Population of Older Persons: Higher Than Previously Reported', Journal of the American Medical Association, vol. 262, no. 18, pp. 2551-2556. https://doi.org/10.1001/jama.1989.03430180093036
Evans, Denis A. ; Funkenstein, H. Harris ; Albert, Marilyn ; Scherr, Paul A. ; Cook, Nancy R. ; Chown, Marilyn J. ; Hebert, Liesi E. ; Hennekens, Charles H. ; Taylor, James O. / Prevalence of Alzheimer’s Disease in a Community Population of Older Persons : Higher Than Previously Reported. In: Journal of the American Medical Association. 1989 ; Vol. 262, No. 18. pp. 2551-2556.
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