Prevalence of alpha-1 antitrypsin deficiency in poorly controlled asthma - Results from the ALA-ACRC low-dose theophylline trial

E. Eden, J. T. Holbrook, M. L. Brantly, G. M. Turino, R. A. Wise

Research output: Contribution to journalArticle


In a study comparing low-dose theophylline to montelukast in poorly controlled asthmatics, 285 subjects consented to be screened for alpha-1 antitrypsin deficiency. Of the 284 for which complete data was available, 10.5% carried a deficiency gene and 2.4% were mildly deficient with an alpha-1 antitrypsin serum level of less than 20 μM. In the non-African-American cohort, an abnormal phenotype occurred in 12% and 2.9% were mildly deficient. Baseline pulmonary function and asthma scores were not significantly different between those with normal and abnormal AAT phenotype. However those with the deficiency tended to show a greater bronchodilator response.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalJournal of Asthma
Issue number8
StatePublished - Oct 1 2007



  • Alpha-1 antitrypsin deficiency
  • Asthma
  • Genetic screening

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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