Prevalence, Impact, and Risk Factors for Hospital-Acquired Conditions after Major Surgical Resection for Cancer: A NSQIP Analysis

Daniela Molena, Benedetto Mungo, Miloslawa Stem, Richard L. Feinberg, Anne O. Lidor

Research output: Contribution to journalArticlepeer-review


Methods: Patients who underwent surgical resection for esophageal, gastric, hepato-biliary, pancreatic, colorectal, and lung cancer were identified using the ACS-NSQIP database (2005–2012). Early surgical outcomes were compared between HAC and non-HAC patients. Modified Poisson regression was used to identify risk factors for developing HAC.

Background: The effectiveness of the CMS nonpayment policy for certain hospital-acquired conditions (HAC) is debated, since their preventability is questionable in several groups of patients. This study aimed to determine the rate of the three most common HAC in major surgical resections for cancer: surgical site infection (SSI), urinary tract infection (UTI), and venous thromboembolism (VTE). Additionally, the association of HAC with patients’ characteristics and their effect on post-operative outcomes were investigated.

Results: Seventy-four thousand three hundred eighty-one patients were identified, of whom 9,479 (12.74 %) developed one or more HAC. HAC patients had significantly higher rates of 30-day mortality, return to operating room, 30-day readmission, had longer LOS, and were less likely to be discharged home. Several peri-operative patients’ factors were significantly associated with HAC.

Conclusion: Our data show that the development of HAC is strongly associated to pre-operative patients’ characteristics and not only to sub-optimal peri-operative care, therefore suggesting that the nonpayment policy might be excessively penalizing.

Original languageEnglish (US)
Pages (from-to)142-151
Number of pages10
JournalJournal of Gastrointestinal Surgery
Issue number1
StatePublished - Jan 2014
Externally publishedYes


  • Cancer
  • Hospital-acquired condition
  • Outcomes
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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