Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh

G. J. Chan, M. Silverman, M. Zaman, A. Murillo-Chaves, A. Mahmud, Abdullah Baqui, T. K. Boyd

Research output: Contribution to journalArticle

Abstract

Objective:To estimate the association between chorioamnionitis, maternal risk factors and birth outcomes.Study Design:A cross-sectional study of 600 pregnant women was conducted at a maternity center in Dhaka from January to October 2011. Outcomes included histologic, microbiologic and clinical chorioamnionitis. Log-binomial models assessed the association between risk factors and histologic chorioamnionitis (HC).Results:Of the 552 women with placental specimens, 70 (12.7%) were classified with HC: 46 (65.7%) with and 24 (34.3%) without fetal involvement. HC was associated with non-physician care (relative risk [RR] 2.04, 95% confidence interval [CI] 1.04 to 4.00), home slab or hanging latrine (RR 1.69, 95% CI 1.10 to 2.62), and lack of tetanus toxoid (RR 1.80, 95% CI 1.03 to 3.14). Women with fever (RR 2.30, 95% CI 1.18 to 4.50) or discolored amniotic fluid (RR 1.74, 95% CI 1.08 to 2.81) had a higher risk of HC. Microbiologic and clinical chorioamnionitis were unreliable HC measures.Conclusion:Prevalence of HC is high; many cases are not captured by clinical diagnosis or microbiologic cultures.Journal of Perinatology advance online publication, 15 September 2016; doi:10.1038/jp.2016.150.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Sep 15 2016

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Chorioamnionitis
Bangladesh
Confidence Intervals
Toilet Facilities
Perinatology
Tetanus Toxoid
Statistical Models
Amniotic Fluid
Publications
Pregnant Women
Fever
Cross-Sectional Studies
Mothers
Parturition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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Chan, G. J., Silverman, M., Zaman, M., Murillo-Chaves, A., Mahmud, A., Baqui, A., & Boyd, T. K. (Accepted/In press). Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh. Journal of Perinatology. https://doi.org/10.1038/jp.2016.150

Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh. / Chan, G. J.; Silverman, M.; Zaman, M.; Murillo-Chaves, A.; Mahmud, A.; Baqui, Abdullah; Boyd, T. K.

In: Journal of Perinatology, 15.09.2016.

Research output: Contribution to journalArticle

Chan, G. J. ; Silverman, M. ; Zaman, M. ; Murillo-Chaves, A. ; Mahmud, A. ; Baqui, Abdullah ; Boyd, T. K. / Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh. In: Journal of Perinatology. 2016.
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abstract = "Objective:To estimate the association between chorioamnionitis, maternal risk factors and birth outcomes.Study Design:A cross-sectional study of 600 pregnant women was conducted at a maternity center in Dhaka from January to October 2011. Outcomes included histologic, microbiologic and clinical chorioamnionitis. Log-binomial models assessed the association between risk factors and histologic chorioamnionitis (HC).Results:Of the 552 women with placental specimens, 70 (12.7{\%}) were classified with HC: 46 (65.7{\%}) with and 24 (34.3{\%}) without fetal involvement. HC was associated with non-physician care (relative risk [RR] 2.04, 95{\%} confidence interval [CI] 1.04 to 4.00), home slab or hanging latrine (RR 1.69, 95{\%} CI 1.10 to 2.62), and lack of tetanus toxoid (RR 1.80, 95{\%} CI 1.03 to 3.14). Women with fever (RR 2.30, 95{\%} CI 1.18 to 4.50) or discolored amniotic fluid (RR 1.74, 95{\%} CI 1.08 to 2.81) had a higher risk of HC. Microbiologic and clinical chorioamnionitis were unreliable HC measures.Conclusion:Prevalence of HC is high; many cases are not captured by clinical diagnosis or microbiologic cultures.Journal of Perinatology advance online publication, 15 September 2016; doi:10.1038/jp.2016.150.",
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