Prevalence and predictors of skin disease in the Women's Interagency HIV Study (WIHS)

Paradi Mirmirani, Nancy A. Hessol, Toby A. Maurer, Timothy G. Berger, Patricia Nguyen, Ann Khalsa, Alejandra Gurtman, Sandra Micci, Mary Young, Susan Holman, Stephen J. Gange, Ruth M. Greenblatt

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We attempted to determine the prevalence and predictors of skin disease in a cohort of women with and at risk for HIV infection. Methods. We analyzed baseline data from a multicenter longitudinal study of HIV infection in women. Results: A total of 2018 HIV-infected women and 557 HIV-uninfected women were included in this analysis. Skin abnormalities were reported more frequently among HIV-infected than uninfected women (63% vs 44%, respectively; odds fatio [OR] 2.10; 95% confidence interval [95% CI], 1.74-2.54). Infected women were also more likely to have more than 2 skin diagnoses (OR, 3.27; 95% CI, 1.31-8.16). Folliculitis, seborrheic dermatitis, herpes zoster, and onychomycosis were more common among HIV-infected women (P < .05). Independent predictors of abnormal findings on skin examination in the infected women were African American face (OR, 1.38; 95% CI, 1.07-1.77), injection drug use (OR, 2.74; 95% CI, 2.11-3.57), CD4+ count less than 50 (OR, 1.68; 95% CI, 1.17-2.42), and high viral loads (100,000-499,999 = OR, 1.77; 95% CI, 1.32-2.37; >499,999 = OR, 2.15; 95% CI, 1.42-3.27). Conclusion. HIV infection was associated with a greater number of skin abnormalities and with specific dermatologic diagnoses. Skin abnormalities were also more common among women with CD4+ cell depletion or higher viral load.

Original languageEnglish (US)
Pages (from-to)785-788
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume44
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Dermatology

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