Prevalence and Persistence of Varicella Antibodies in Previously Immunized Children and Youth with Perinatal HIV-1 Infection

Murli U. Purswani, Brad Karalius, Tzy Jyun Yao, D. Scott Schmid, Sandra K. Burchett, George K. Siberry, Kunjal Patel, Russell B. Van Dyke, Ram Yogev, Ram Yogev, Margaret Ann Sanders, Kathleen Malee, Scott Hunter, William Shearer, Mary Paul, Norma Cooper, Lynnette Harris, Murli Purswani, Mahboobullah Baig, Anna CintronAna Puga, Sandra Navarro, Patricia Garvie, James Blood, Sandra Burchett, Nancy Karthas, Betsy Kammerer, Andrew Wiznia, Marlene Burey, Molly Nozyce, Arry Dieudonne, Linda Bettica, Susan Adubato, Janet Chen, Maria Garcia Bulkley, Latreaca Ivey, Mitzie Grant, Katherine Knapp, Kim Allison, Megan Wilkins, Midnela Acevedo-Flores, Heida Rios, Vivian Olivera, Margarita Silio, Medea Jones, Patricia Sirois, Stephen Spector, Kim Norris, Sharon Nichols, Elizabeth Mcfarland, Alisa Katai, Jennifer Dunn, Suzanne Paul, Gwendolyn Scott, Patricia Bryan, Elizabeth Willen

Research output: Contribution to journalArticle

Abstract

Background.Two doses of live-attenuated varicella-zoster vaccine are recommended for human immunodeficiency virus 1 (HIV-1)-infected children with CD4% ≥15%. We determined the prevalence and persistence of antibody in immunized children with perinatal HIV (PHIV) and their association with number of vaccinations, combination antiretroviral therapy (cART), and HIV status. Methods.The Adolescent Master Protocol is an observational study of children with PHIV and perinatally HIV-exposed but uninfected (PHEU) children conducted at 15 US sites. In a cross-sectional analysis, we tested participants' most recent stored sera for varicella antibody using whole-cell and glycoprotein enzyme-linked immunosorbent assay. Seropositivity predictors were identified using multivariable logistic regression models and C statistics. Results.Samples were available for 432 children with PHIV and 221 PHEU children; 82% of children with PHIV and 97% of PHEU children were seropositive (P 94% at all intervals. Independent predictors of seropositivity among children with PHIV were receipt of 2 vaccine doses, receipt of 1 dose while on ≥3 months of cART, compared with none (adjusted odds ratio [aOR]: 14.0 and 2.8, respectively; P

Original languageEnglish (US)
Pages (from-to)106-114
Number of pages9
JournalClinical Infectious Diseases
Volume62
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Chickenpox
Virus Diseases
HIV-1
HIV
Antibodies
Herpes Zoster Vaccine
Logistic Models
Chickenpox Vaccine
Attenuated Vaccines
Observational Studies
Glycoproteins
Vaccination
Vaccines
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Odds Ratio

Keywords

  • antibodies
  • HIV
  • perinatal
  • vaccine
  • varicella

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Purswani, M. U., Karalius, B., Yao, T. J., Schmid, D. S., Burchett, S. K., Siberry, G. K., ... Willen, E. (2016). Prevalence and Persistence of Varicella Antibodies in Previously Immunized Children and Youth with Perinatal HIV-1 Infection. Clinical Infectious Diseases, 62(1), 106-114. https://doi.org/10.1093/cid/civ734

Prevalence and Persistence of Varicella Antibodies in Previously Immunized Children and Youth with Perinatal HIV-1 Infection. / Purswani, Murli U.; Karalius, Brad; Yao, Tzy Jyun; Schmid, D. Scott; Burchett, Sandra K.; Siberry, George K.; Patel, Kunjal; Van Dyke, Russell B.; Yogev, Ram; Yogev, Ram; Sanders, Margaret Ann; Malee, Kathleen; Hunter, Scott; Shearer, William; Paul, Mary; Cooper, Norma; Harris, Lynnette; Purswani, Murli; Baig, Mahboobullah; Cintron, Anna; Puga, Ana; Navarro, Sandra; Garvie, Patricia; Blood, James; Burchett, Sandra; Karthas, Nancy; Kammerer, Betsy; Wiznia, Andrew; Burey, Marlene; Nozyce, Molly; Dieudonne, Arry; Bettica, Linda; Adubato, Susan; Chen, Janet; Bulkley, Maria Garcia; Ivey, Latreaca; Grant, Mitzie; Knapp, Katherine; Allison, Kim; Wilkins, Megan; Acevedo-Flores, Midnela; Rios, Heida; Olivera, Vivian; Silio, Margarita; Jones, Medea; Sirois, Patricia; Spector, Stephen; Norris, Kim; Nichols, Sharon; Mcfarland, Elizabeth; Katai, Alisa; Dunn, Jennifer; Paul, Suzanne; Scott, Gwendolyn; Bryan, Patricia; Willen, Elizabeth.

In: Clinical Infectious Diseases, Vol. 62, No. 1, 01.01.2016, p. 106-114.

Research output: Contribution to journalArticle

Purswani, MU, Karalius, B, Yao, TJ, Schmid, DS, Burchett, SK, Siberry, GK, Patel, K, Van Dyke, RB, Yogev, R, Yogev, R, Sanders, MA, Malee, K, Hunter, S, Shearer, W, Paul, M, Cooper, N, Harris, L, Purswani, M, Baig, M, Cintron, A, Puga, A, Navarro, S, Garvie, P, Blood, J, Burchett, S, Karthas, N, Kammerer, B, Wiznia, A, Burey, M, Nozyce, M, Dieudonne, A, Bettica, L, Adubato, S, Chen, J, Bulkley, MG, Ivey, L, Grant, M, Knapp, K, Allison, K, Wilkins, M, Acevedo-Flores, M, Rios, H, Olivera, V, Silio, M, Jones, M, Sirois, P, Spector, S, Norris, K, Nichols, S, Mcfarland, E, Katai, A, Dunn, J, Paul, S, Scott, G, Bryan, P & Willen, E 2016, 'Prevalence and Persistence of Varicella Antibodies in Previously Immunized Children and Youth with Perinatal HIV-1 Infection', Clinical Infectious Diseases, vol. 62, no. 1, pp. 106-114. https://doi.org/10.1093/cid/civ734
Purswani, Murli U. ; Karalius, Brad ; Yao, Tzy Jyun ; Schmid, D. Scott ; Burchett, Sandra K. ; Siberry, George K. ; Patel, Kunjal ; Van Dyke, Russell B. ; Yogev, Ram ; Yogev, Ram ; Sanders, Margaret Ann ; Malee, Kathleen ; Hunter, Scott ; Shearer, William ; Paul, Mary ; Cooper, Norma ; Harris, Lynnette ; Purswani, Murli ; Baig, Mahboobullah ; Cintron, Anna ; Puga, Ana ; Navarro, Sandra ; Garvie, Patricia ; Blood, James ; Burchett, Sandra ; Karthas, Nancy ; Kammerer, Betsy ; Wiznia, Andrew ; Burey, Marlene ; Nozyce, Molly ; Dieudonne, Arry ; Bettica, Linda ; Adubato, Susan ; Chen, Janet ; Bulkley, Maria Garcia ; Ivey, Latreaca ; Grant, Mitzie ; Knapp, Katherine ; Allison, Kim ; Wilkins, Megan ; Acevedo-Flores, Midnela ; Rios, Heida ; Olivera, Vivian ; Silio, Margarita ; Jones, Medea ; Sirois, Patricia ; Spector, Stephen ; Norris, Kim ; Nichols, Sharon ; Mcfarland, Elizabeth ; Katai, Alisa ; Dunn, Jennifer ; Paul, Suzanne ; Scott, Gwendolyn ; Bryan, Patricia ; Willen, Elizabeth. / Prevalence and Persistence of Varicella Antibodies in Previously Immunized Children and Youth with Perinatal HIV-1 Infection. In: Clinical Infectious Diseases. 2016 ; Vol. 62, No. 1. pp. 106-114.
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AU - Karalius, Brad

AU - Yao, Tzy Jyun

AU - Schmid, D. Scott

AU - Burchett, Sandra K.

AU - Siberry, George K.

AU - Patel, Kunjal

AU - Van Dyke, Russell B.

AU - Yogev, Ram

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AU - Sanders, Margaret Ann

AU - Malee, Kathleen

AU - Hunter, Scott

AU - Shearer, William

AU - Paul, Mary

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AU - Harris, Lynnette

AU - Purswani, Murli

AU - Baig, Mahboobullah

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AU - Puga, Ana

AU - Navarro, Sandra

AU - Garvie, Patricia

AU - Blood, James

AU - Burchett, Sandra

AU - Karthas, Nancy

AU - Kammerer, Betsy

AU - Wiznia, Andrew

AU - Burey, Marlene

AU - Nozyce, Molly

AU - Dieudonne, Arry

AU - Bettica, Linda

AU - Adubato, Susan

AU - Chen, Janet

AU - Bulkley, Maria Garcia

AU - Ivey, Latreaca

AU - Grant, Mitzie

AU - Knapp, Katherine

AU - Allison, Kim

AU - Wilkins, Megan

AU - Acevedo-Flores, Midnela

AU - Rios, Heida

AU - Olivera, Vivian

AU - Silio, Margarita

AU - Jones, Medea

AU - Sirois, Patricia

AU - Spector, Stephen

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AU - Nichols, Sharon

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