Prevalence and levels of antibodies to the circumsporozoite protein of plasmodium falciparum in an endemic area and their relationship to resistance against malaria infection

Fulvio Esposito, Stefania Lombardi, David Modiano, Fidel Zavala, Jan Reeme, Lansina Lamizana, Mario Coluzzi, Ruth S. Nussenzweig

Research output: Contribution to journalArticle

Abstract

A study on malaria transmission, prevalence of infection and anti-sporozoite antibodies was carried out in Burkina Faso (West Africa). The prevalence and the levels of antibodies to (NANP)3 were found to be related to the entomological sporozoite inoculation rates measured at the same time in a defined area. The major inducer of anti-(NANP)3 antibody production under field conditions is sporozoite inoculation by infected mosquitoes. Levels of antibodies to (NANP)3 vary considerably with age and transmission season. High levels of anti-(NANP)3 antibodies raised under field conditions might offer protection against small inocula of sporozoites.

Original languageEnglish (US)
Pages (from-to)827-832
Number of pages6
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume82
Issue number6
DOIs
StatePublished - Nov 1 1988

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ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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