Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection

Ahvie Herskowitz, David Vlahov, Sharon Willoughby, Richard E Chaisson, Steven P Schulman, David A. Neumann, Kenneth L. Baughman

Research output: Contribution to journalArticle

Abstract

The prevalence and incidence of left ventricular (LV) dysfunction was examined in patients infected with the human immunodeficiency virus (HIV). Sixty-nine randomly selected patients diagnosed with HIV infection who were followed in HIV clinics were prospectively evaluated by 2-dimensional echocardiography. Mean follow-up duration was 11 months. Additionally, 39 consecutive HIV-infected patients referred to the Cardiomyopathy Service and found to have LV dysfunction by 2-dimensional echocardiography were also studied. Of the 39 referred patients, 34 (87%) were referred for recent onset, unexplained, congestive heart failure. During this time, the HIV clinic population comprised 1,819 alive and actively followed patients; the 39 cardiomyopathy referrals therefore constituted a crude rate of 2.1% for this population. Of the 69 prospectively studied patients without clinical heart disease, a 14.5% prevalence of global LV hypokinesia and an incidence of 18%/patient-year were found. During a maximal 18-month follow-up period, 4 prospective patients (5.8%) developed symptoms of congestive heart failure. A greater proportion of prospective and referred patients with LV dysfunction had CD4 counts 3 (62 and 79%, respectively) than did that of those without LV dysfunction (35%). In conclusion, the high rate of unexpected LV dysfunction in this HIV-infected population suggests that early cardiac contractile abnormalities may involve a significant number of patients, most of whom have low CD4 counts. A subgroup of these patients appears to progress to symptomatic congestive heart failure.

Original languageEnglish (US)
Pages (from-to)955-958
Number of pages4
JournalThe American Journal of Cardiology
Volume71
Issue number11
DOIs
StatePublished - Apr 15 1993

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Left Ventricular Dysfunction
Virus Diseases
HIV
Incidence
Heart Failure
CD4 Lymphocyte Count
Cardiomyopathies
Echocardiography
Population
Hypokinesia
Heart Diseases
Referral and Consultation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection. / Herskowitz, Ahvie; Vlahov, David; Willoughby, Sharon; Chaisson, Richard E; Schulman, Steven P; Neumann, David A.; Baughman, Kenneth L.

In: The American Journal of Cardiology, Vol. 71, No. 11, 15.04.1993, p. 955-958.

Research output: Contribution to journalArticle

Herskowitz, Ahvie ; Vlahov, David ; Willoughby, Sharon ; Chaisson, Richard E ; Schulman, Steven P ; Neumann, David A. ; Baughman, Kenneth L. / Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection. In: The American Journal of Cardiology. 1993 ; Vol. 71, No. 11. pp. 955-958.
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