Prevalence and incidence of hepatitis C virus infection among young adult injection drug users

Richard S. Garfein, Meg Caroline Doherty, Edgar R. Monterroso, David L Thomas, Kenrad Edwin Nelson, David Vlahov

Research output: Contribution to journalArticle

Abstract

Through community-based outreach, young adult injection drug users (IDUs) were enrolled in a prospective study of the prevalence, incidence, and risk factors for hepatitis C virus (HCV) infection. Demographics and information on sexual and injecting practices were collected during semiannual interviews, and HCV infection was evaluated using a second- generation antibody assay. Of the 229 participants, 86 (37.6%) were HCV- seropositive at baseline. After adjusting for injecting frequency and duration by logistic regression, HCV seroprevalence was independently associated with reusing syringes at least once in the past 6 months (odds ratio [OR] = 3.81, 95% confidence interval [CI] 1.39-11.00), injecting the first time with someone ≤5 years older (OR = 2.99; 95% CI, 1.43-6.23) or alone (OR = 4.02; 95% CI, 1.12-14.43) versus with someone

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume18
Issue numberSUPPL.
StatePublished - Jul 1 1998

Fingerprint

Virus Diseases
Drug Users
Hepacivirus
Young Adult
Injections
Odds Ratio
Incidence
Confidence Intervals
Community-Institutional Relations
Seroepidemiologic Studies
Syringes
Logistic Models
Demography
Prospective Studies
Interviews
Antibodies

Keywords

  • Hepatitis C virus
  • Initiation
  • Injection drug use
  • Seroincidence
  • Seroprevalence
  • Syringe sharing
  • Young adult

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

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title = "Prevalence and incidence of hepatitis C virus infection among young adult injection drug users",
abstract = "Through community-based outreach, young adult injection drug users (IDUs) were enrolled in a prospective study of the prevalence, incidence, and risk factors for hepatitis C virus (HCV) infection. Demographics and information on sexual and injecting practices were collected during semiannual interviews, and HCV infection was evaluated using a second- generation antibody assay. Of the 229 participants, 86 (37.6{\%}) were HCV- seropositive at baseline. After adjusting for injecting frequency and duration by logistic regression, HCV seroprevalence was independently associated with reusing syringes at least once in the past 6 months (odds ratio [OR] = 3.81, 95{\%} confidence interval [CI] 1.39-11.00), injecting the first time with someone ≤5 years older (OR = 2.99; 95{\%} CI, 1.43-6.23) or alone (OR = 4.02; 95{\%} CI, 1.12-14.43) versus with someone",
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AU - Doherty, Meg Caroline

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AU - Nelson, Kenrad Edwin

AU - Vlahov, David

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