Prevalence and incidence of antimicrobial-resistant organisms among hospitalized inflammatory bowel disease patients

Alon Vaisman, Kevin Pivovarov, Allison McGeer, Barbara Willey, Bjug Borgundvaag, Vanessa Porter, Piraveina Gnanasuntharam, Yanliang Wei, Geoffrey C. Nguyen

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Abstract

BACKGROUND: Patients with inflammatory bowel disease (IBD) experience frequent hospitalizations and use of immunosuppressive medications, which may predispose them to colonization with antimicrobial-resistant organisms (ARO). OBJECTIVE: To determine the prevalence of ARO colonization on admission to hospital and the incidence of infection during hospital-ization among hospitalized IBD patients. METHODS: A chart review comparing the prevalence of colonization and incidence of infection with methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL) in hospitalized IBD patients with those of non-IBD controls was performed. RESULTS: On admission, there were no significant differences between IBD inpatients and controls in the prevalence of colonization of methicillin-resistant S aureus (1.0% versus 1.2%; P=0.74), vancomycin-resistant enterococci (0.2% versus 0%; P=1.0) or ESBL (4.1% versus 5.5%; P=0.33). Pooling data from historical clinic-based cohorts, IBD patients were more likely than controls to have ESBL colonization (19% versus 6.6%; P<0.05). Antibiotic use on admission was associated with ESBL colonization among IBD inpatients (OR 4.2 [95% CI 1.4 to 12.6]). The incidence of ARO infections during hospitalization was not significantly different between IBD patients and controls. Among IBD patients who acquired ARO infections during hospitalizations, the mean time interval from admission to infection was shorter for those who were already colonized with ARO on admission. CONCLUSIONS: This particular population of hospitalized IBD patients was not shown to have a higher prevalence or incidence of ARO colonization or infection compared with non-IBD inpatients.

Original languageEnglish (US)
Pages (from-to)e117-e121
JournalCanadian Journal of Infectious Diseases and Medical Microbiology
Volume24
Issue number4
StatePublished - Jan 1 2013

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Keywords

  • Crohn disease
  • Extended spectrum beta-lactamase
  • Inflammatory bowel disease
  • Methicillin-resistant Staphylococcus aureus
  • Ulcerative colitis
  • Vancomycin-resistant enterococci

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Vaisman, A., Pivovarov, K., McGeer, A., Willey, B., Borgundvaag, B., Porter, V., Gnanasuntharam, P., Wei, Y., & Nguyen, G. C. (2013). Prevalence and incidence of antimicrobial-resistant organisms among hospitalized inflammatory bowel disease patients. Canadian Journal of Infectious Diseases and Medical Microbiology, 24(4), e117-e121.