TY - JOUR
T1 - Prevalence and correlates of HPV among women attending family-planning clinics in Thailand
AU - Marks, Morgan A.
AU - Gupta, Swati
AU - Liaw, Kai Li
AU - Tadesse, Amha
AU - Kim, Esther
AU - Phongnarisorn, Chailert
AU - Wootipoom, Virach
AU - Yuenyao, Pissamai
AU - Vipupinyo, Charoen
AU - Rugpao, Sungwal
AU - Sriplienchan, Somchai
AU - Gravitt, Patti E.
AU - Celentano, David D.
N1 - Funding Information:
This work was funded in part by the NIAID pre-doctoral training fellowship in sexually transmitted infections (5T32AI050056-09). This study was funded by Merck & Co. Inc. This data was previously presented as an oral talk entitled “Human papillomavirus genotype and proportion of CIN 2/3 attributable to high-risk HPV type in a large cohort of Thai women”. at the 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China (2007).
Publisher Copyright:
© Marks et al.
PY - 2015/3/27
Y1 - 2015/3/27
N2 - Background: Cervical cancer is the most common cancer among women of reproductive age in Thailand. However, information on the prevalence and correlates of anogenital HPV infection in Thailand is sparse. Methods: HPV genotype information, reproductive factors, sexual behavior, other STI and clinical information, and cervical cytology and histology were assessed at enrollment among one thousand two hundred and fifty-six (n = 1,256) HIV negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. The type-specific prevalence of HPV was estimated using cervical swab specimens from healthy women and women with a diagnosis of CIN 2/3 at baseline. Prevalence ratios (95% CI) were estimated using Poisson regression to quantify the association of demographic, behavioral, and clinical correlates with prevalent HPV infection. Results: Overall, 307 (24.6%) and 175 (14.0%) of women were positive for any HPV type and any HR-HPV type, respectively; the most common types were 72, 52, 62, and 16. Among women diagnosed with CIN 2/3 at enrollment (n = 11), the most prevalent HPV types were 52 and 16. In multivariate analysis, HPV prevalence at enrollment was higher among women with: long-term combined oral contraceptive use, a higher number of lifetime sexual partners, a prior Chlamydia infection, and a current diagnosis of Bacterial Vaginosis. Conclusion: The study findings provide important information that can be used in the evaluation of primary and secondary interventions designed to reduce the burden of cervical cancer in Thailand.
AB - Background: Cervical cancer is the most common cancer among women of reproductive age in Thailand. However, information on the prevalence and correlates of anogenital HPV infection in Thailand is sparse. Methods: HPV genotype information, reproductive factors, sexual behavior, other STI and clinical information, and cervical cytology and histology were assessed at enrollment among one thousand two hundred and fifty-six (n = 1,256) HIV negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. The type-specific prevalence of HPV was estimated using cervical swab specimens from healthy women and women with a diagnosis of CIN 2/3 at baseline. Prevalence ratios (95% CI) were estimated using Poisson regression to quantify the association of demographic, behavioral, and clinical correlates with prevalent HPV infection. Results: Overall, 307 (24.6%) and 175 (14.0%) of women were positive for any HPV type and any HR-HPV type, respectively; the most common types were 72, 52, 62, and 16. Among women diagnosed with CIN 2/3 at enrollment (n = 11), the most prevalent HPV types were 52 and 16. In multivariate analysis, HPV prevalence at enrollment was higher among women with: long-term combined oral contraceptive use, a higher number of lifetime sexual partners, a prior Chlamydia infection, and a current diagnosis of Bacterial Vaginosis. Conclusion: The study findings provide important information that can be used in the evaluation of primary and secondary interventions designed to reduce the burden of cervical cancer in Thailand.
KW - CIN
KW - Epidemiology
KW - HPV
KW - Thailand
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U2 - 10.1186/s12879-015-0886-z
DO - 10.1186/s12879-015-0886-z
M3 - Article
C2 - 25887797
AN - SCOPUS:84926362012
SN - 1471-2334
VL - 15
JO - BMC infectious diseases
JF - BMC infectious diseases
IS - 1
M1 - 159
ER -