Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: The German Chronic Kidney Disease (GCKD) study

GCKD Study Investigators

Research output: Contribution to journalArticle

Abstract

BackgroundReduced kidney function is a risk factor for hyperuricaemia and gout, but limited information on the burden of gout is available from studies of patients with chronic kidney disease (CKD). We therefore examined the prevalence and correlates of gout in the large prospective observational German Chronic Kidney Disease (GCKD) study. MethodsData from 5085 CKD patients aged 18-74 years with an estimated glomerular filtration rate (eGFR) of 30-2 or eGFR ≥60 and overt proteinuria at recruitment and non-missing values for self-reported gout, medications and urate measurements from a central laboratory were evaluated. ResultsThe overall prevalence of gout was 24.3%, and increased from 16.0% in those with eGFR ≥60 mL/min/1.73 m2 to 35.6% in those with eGFR

Original languageEnglish (US)
Pages (from-to)613-621
Number of pages9
JournalNephrology Dialysis Transplantation
Volume30
Issue number4
DOIs
StatePublished - Apr 1 2015

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Gout
Chronic Renal Insufficiency
Glomerular Filtration Rate
Uric Acid
Proteinuria
Kidney

Keywords

  • chronic kidney disease
  • correlates
  • estimated glomerular filtration rate
  • GCKD study
  • gout epidemiology
  • observational study

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease : The German Chronic Kidney Disease (GCKD) study. / GCKD Study Investigators.

In: Nephrology Dialysis Transplantation, Vol. 30, No. 4, 01.04.2015, p. 613-621.

Research output: Contribution to journalArticle

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title = "Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: The German Chronic Kidney Disease (GCKD) study",
abstract = "BackgroundReduced kidney function is a risk factor for hyperuricaemia and gout, but limited information on the burden of gout is available from studies of patients with chronic kidney disease (CKD). We therefore examined the prevalence and correlates of gout in the large prospective observational German Chronic Kidney Disease (GCKD) study. MethodsData from 5085 CKD patients aged 18-74 years with an estimated glomerular filtration rate (eGFR) of 30-2 or eGFR ≥60 and overt proteinuria at recruitment and non-missing values for self-reported gout, medications and urate measurements from a central laboratory were evaluated. ResultsThe overall prevalence of gout was 24.3{\%}, and increased from 16.0{\%} in those with eGFR ≥60 mL/min/1.73 m2 to 35.6{\%} in those with eGFR",
keywords = "chronic kidney disease, correlates, estimated glomerular filtration rate, GCKD study, gout epidemiology, observational study",
author = "{GCKD Study Investigators} and Jiaojiao Jing and Kielstein, {Jan T.} and Schultheiss, {Ulla T.} and Thomas Sitter and Titze, {Stephanie I.} and Schaeffner, {Elke S.} and {McAdams Demarco}, {Mara Ann} and Florian Kronenberg and Eckardt, {Kai Uwe} and Anna K{\"o}ttgen and Prokosch, {Hans Ulrich} and Barbara B{\"a}rthlein and Andr{\'e} Reis and Ekici, {Arif B.} and Olaf Gefeller and Hilgers, {Karl F.} and Silvia H{\"u}bner and Susanne Avenda{\~n}o and Dinah Becker-Grosspitsch and Nina Hauck and Seuchter, {Susanne A.} and Birgit Hausknecht and Marion Rittmeier and Anke Weigel and Andreas Beck and Thomas Ganslandt and Sabine Knispel and Thomas Dressel and Martina Malzer and J{\"u}rgen Floege and Frank Eitner and Georg Schlieper and Katharina Findeisen and Elfriede Arweiler and Sabine Ernst and Mario Unger and Stefan Lipski and Seema Baid-Agrawal and Kerstin Petzold and Ralf Schindler and Simone Meder and Erna Mitsch and Ursula Reinhard and Gerd Walz and Hermann Haller and Johan Lorenzen and Petra Otto and Claudia Sommerer and Claudia F{\"o}llinger and Martin Zeier",
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T1 - Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease

T2 - The German Chronic Kidney Disease (GCKD) study

AU - GCKD Study Investigators

AU - Jing, Jiaojiao

AU - Kielstein, Jan T.

AU - Schultheiss, Ulla T.

AU - Sitter, Thomas

AU - Titze, Stephanie I.

AU - Schaeffner, Elke S.

AU - McAdams Demarco, Mara Ann

AU - Kronenberg, Florian

AU - Eckardt, Kai Uwe

AU - Köttgen, Anna

AU - Prokosch, Hans Ulrich

AU - Bärthlein, Barbara

AU - Reis, André

AU - Ekici, Arif B.

AU - Gefeller, Olaf

AU - Hilgers, Karl F.

AU - Hübner, Silvia

AU - Avendaño, Susanne

AU - Becker-Grosspitsch, Dinah

AU - Hauck, Nina

AU - Seuchter, Susanne A.

AU - Hausknecht, Birgit

AU - Rittmeier, Marion

AU - Weigel, Anke

AU - Beck, Andreas

AU - Ganslandt, Thomas

AU - Knispel, Sabine

AU - Dressel, Thomas

AU - Malzer, Martina

AU - Floege, Jürgen

AU - Eitner, Frank

AU - Schlieper, Georg

AU - Findeisen, Katharina

AU - Arweiler, Elfriede

AU - Ernst, Sabine

AU - Unger, Mario

AU - Lipski, Stefan

AU - Baid-Agrawal, Seema

AU - Petzold, Kerstin

AU - Schindler, Ralf

AU - Meder, Simone

AU - Mitsch, Erna

AU - Reinhard, Ursula

AU - Walz, Gerd

AU - Haller, Hermann

AU - Lorenzen, Johan

AU - Otto, Petra

AU - Sommerer, Claudia

AU - Föllinger, Claudia

AU - Zeier, Martin

PY - 2015/4/1

Y1 - 2015/4/1

N2 - BackgroundReduced kidney function is a risk factor for hyperuricaemia and gout, but limited information on the burden of gout is available from studies of patients with chronic kidney disease (CKD). We therefore examined the prevalence and correlates of gout in the large prospective observational German Chronic Kidney Disease (GCKD) study. MethodsData from 5085 CKD patients aged 18-74 years with an estimated glomerular filtration rate (eGFR) of 30-2 or eGFR ≥60 and overt proteinuria at recruitment and non-missing values for self-reported gout, medications and urate measurements from a central laboratory were evaluated. ResultsThe overall prevalence of gout was 24.3%, and increased from 16.0% in those with eGFR ≥60 mL/min/1.73 m2 to 35.6% in those with eGFR

AB - BackgroundReduced kidney function is a risk factor for hyperuricaemia and gout, but limited information on the burden of gout is available from studies of patients with chronic kidney disease (CKD). We therefore examined the prevalence and correlates of gout in the large prospective observational German Chronic Kidney Disease (GCKD) study. MethodsData from 5085 CKD patients aged 18-74 years with an estimated glomerular filtration rate (eGFR) of 30-2 or eGFR ≥60 and overt proteinuria at recruitment and non-missing values for self-reported gout, medications and urate measurements from a central laboratory were evaluated. ResultsThe overall prevalence of gout was 24.3%, and increased from 16.0% in those with eGFR ≥60 mL/min/1.73 m2 to 35.6% in those with eGFR

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KW - correlates

KW - estimated glomerular filtration rate

KW - GCKD study

KW - gout epidemiology

KW - observational study

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