TY - JOUR
T1 - Prevalence and classification of mild cognitive impairment in the cardiovascular health study cognition study
AU - Lopez, Oscar L.
AU - Jagust, William J.
AU - DeKosky, Steven T.
AU - Becker, James T.
AU - Fitzpatrick, Annette
AU - Dulberg, Corinne
AU - Breitner, John
AU - Lyketsos, Constantine
AU - Jones, Beverly
AU - Kawas, Claudia
AU - Carlson, Michelle
AU - Kuller, Lewis H.
PY - 2003/10
Y1 - 2003/10
N2 - Objective: To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study. Design: The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort. Setting: Multicenter population study. Patients: We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI. ti;6Main Outcome Measures: The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center (n = 927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits-type. Results: The overall prevalence of MCI was 19% (465 of 2470 participants); prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits-type was 16%. Conclusions: Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogenous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits-type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions.
AB - Objective: To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study. Design: The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort. Setting: Multicenter population study. Patients: We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI. ti;6Main Outcome Measures: The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center (n = 927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits-type. Results: The overall prevalence of MCI was 19% (465 of 2470 participants); prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits-type was 16%. Conclusions: Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogenous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits-type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions.
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U2 - 10.1001/archneur.60.10.1385
DO - 10.1001/archneur.60.10.1385
M3 - Article
C2 - 14568808
AN - SCOPUS:0141993614
SN - 0003-9942
VL - 60
SP - 1385
EP - 1389
JO - Archives of neurology
JF - Archives of neurology
IS - 10
ER -