Prevalence and associations with hepatitis B and hepatitis C infection among HIV-infected adults in South Africa

Christopher J. Hoffmann, D. Dayal, M. Cheyip, J. A. McIntyre, G. E. Gray, S. Conway, N. A. Martinson

Research output: Contribution to journalArticle

Abstract

We assessed prevalence and factors associated with hepatitis B in a cross section of HIV-infected primary care and antinatal clinic patients in South Africa and evaluated a rapid hepatitis B surface antigen (HBsAg) assay. We enrolled 998 patients; 88% were women, median age was 29 years and median CD4 count was 354 cells/mm3. HBsAg enzyme-linked immunosorbent assay (ELISA), anti-hepatitis B core (HBc) antibodies and hepatitis C virus antibody were positive among 4.2%, 37% and 0.1% of subjects, respectively. Univariate and multivariate associations were assessed using logistic regression. Anti-HBc antibodies were associated with alcohol use, traditional medicines and higher CD4 counts; HBsAg positivity was associated with lower CD4. Compared with the HBsAg ELISA, a rapid HBsAg test had a sensitivity of 75.0% and specificity of 99.6%. In conclusion, we identified a moderate prevalence of both HBsAg and anti-HBc. Importantly, we found that subjects with HBsAg positivity had lower CD4 counts.

Original languageEnglish (US)
Pages (from-to)e10-e13
JournalInternational Journal of STD and AIDS
Volume23
Issue number10
DOIs
StatePublished - Nov 5 2012

Keywords

  • Africa
  • Co-infection
  • HBsAg
  • HIV/AIDS
  • Hepatitis B
  • Hepatitis C
  • Rapid test
  • Surface antigen

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

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