Pretreatment blood-brain barrier disruption and post-endovascular intracranial hemorrhage

Richard Leigh, Søren Christensen, Bruce C.V. Campbell, Michael P. Marks, Gregory W. Albers, Maarten G. Lansberg

Research output: Contribution to journalArticlepeer-review


Objective: This study sought to confirm the relationship between the degree of blood-brain barrier (BBB) damage and the severity of intracranial hemorrhage (ICH) in a population of patients who received endovascular therapy. Methods: The degree of BBB disruption on pretreatment MRI scans was analyzed, blinded to follow-up data, in the DEFUSE 2 cohort in which patients had endovascular therapy within 12 hours of stroke onset. BBB disruption was compared with ICH grade previously established by the DEFUSE 2 core lab. A prespecified threshold for predicting parenchymal hematoma (PH) was tested. Results: Of the 108 patients in the DEFUSE 2 trial, 100 had adequate imaging and outcome data and were included in this study; 24 developed PH. Increasing amounts of BBB disruption on pretreatment MRIs was associated with increasing severity of ICH grade (p 0.004). BBB disruption on the pretreatment scan was associated with PH (p 0.020) with an odds ratio for developing PH of 1.69 for each 10% increase in BBB disruption (95% confidence interval 1.09-2.64), although a reliably predictive threshold was not identified. Conclusions: The amount of BBB disruption on pretreatment MRI is associated with the severity of ICH after acute intervention. This relationship has now been identified in patients receiving IV, endovascular, and combined therapies. Further study is needed to determine its role in guiding treatment.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
Issue number3
StatePublished - Jul 19 2016
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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