Pretreatment and Posttreatment Evaluation of Hemodynamic and Metabolic Parameters in Intracranial Dural Arteriovenous Fistulae with Cortical Venous Reflux

Satoshi Kuroda, Koji Furukawa, Tohru Shiga, Satoshi Ushikoshi, Chietsugu Katoh, Takeshi Aoki, Tatsuya Ishikawa, Kiyohiro Houkin, Nagara Tamaki, Yoshinobu Iwasaki, Warren R. Selman, Arthur L. Day, Philip V. Theodosopoulos, Daniele Rigamonti, Wendy Spangler, Robert F. Spetzler

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Retrograde drainage into the cortical veins results in poor outcome in patients with an intracranial dural arteriovenous fistula. However, the pathophysiological features of dural arteriovenous fistulae remain obscure. This study aimed to clarify hemodynamic and metabolic conditions in these patients using positron emission tomography. METHODS: This study included eight patients with an intracranial dural arteriovenous fistula. All patients had cortical venous reflux, as demonstrated by angiography. Regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional cerebral metabolic rate for oxygen, and regional oxygen extraction fraction (rOEF) were measured before and after surgical or endovascular treatment using positron emission tomography. RESULTS: Pretreatment positron emission tomographic studies revealed that all patients had abnormal hemodynamic and metabolic parameters in the area that was drained by the involved cortical veins. A severe increase in rCBV was noted in seven of the eight patients. A significant decrease in rCBF also was observed in all eight patients. A negative correlation was observed between rCBF and rCBV. Three patients had an elevated rOEF. Oxygen metabolism was impaired in seven patients. All patients underwent successful treatment. Follow-up studies demonstrated significant improvements in rCBF, rCBV, and regional cerebral metabolic rate for oxygen. The improvement in regional cerebral metabolic rate for oxygen varied among the patients. Normalization of rOEF also was confirmed in three patients who had increased rOEF before the treatment. CONCLUSION: The present results suggest that hemodynamic and metabolic characteristics vary widely among patients with cortical venous reflux. It is essential to precisely evaluate hemodynamic and metabolic conditions to predict their outcomes and therapeutic effects.

Original languageEnglish (US)
Pages (from-to)585-592
Number of pages8
JournalNeurosurgery
Volume54
Issue number3
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Central Nervous System Vascular Malformations
Hemodynamics
Cerebrovascular Circulation
Oxygen
Regional Blood Flow
Positron-Emission Tomography
Veins
Therapeutic Uses

Keywords

  • Cerebral blood flow
  • Cerebral blood volume
  • Cerebral oxygen metabolism
  • Grading system
  • Intracranial dural arteriovenous fistula
  • Positron emission tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Kuroda, S., Furukawa, K., Shiga, T., Ushikoshi, S., Katoh, C., Aoki, T., ... Spetzler, R. F. (2004). Pretreatment and Posttreatment Evaluation of Hemodynamic and Metabolic Parameters in Intracranial Dural Arteriovenous Fistulae with Cortical Venous Reflux. Neurosurgery, 54(3), 585-592.

Pretreatment and Posttreatment Evaluation of Hemodynamic and Metabolic Parameters in Intracranial Dural Arteriovenous Fistulae with Cortical Venous Reflux. / Kuroda, Satoshi; Furukawa, Koji; Shiga, Tohru; Ushikoshi, Satoshi; Katoh, Chietsugu; Aoki, Takeshi; Ishikawa, Tatsuya; Houkin, Kiyohiro; Tamaki, Nagara; Iwasaki, Yoshinobu; Selman, Warren R.; Day, Arthur L.; Theodosopoulos, Philip V.; Rigamonti, Daniele; Spangler, Wendy; Spetzler, Robert F.

In: Neurosurgery, Vol. 54, No. 3, 03.2004, p. 585-592.

Research output: Contribution to journalArticle

Kuroda, S, Furukawa, K, Shiga, T, Ushikoshi, S, Katoh, C, Aoki, T, Ishikawa, T, Houkin, K, Tamaki, N, Iwasaki, Y, Selman, WR, Day, AL, Theodosopoulos, PV, Rigamonti, D, Spangler, W & Spetzler, RF 2004, 'Pretreatment and Posttreatment Evaluation of Hemodynamic and Metabolic Parameters in Intracranial Dural Arteriovenous Fistulae with Cortical Venous Reflux', Neurosurgery, vol. 54, no. 3, pp. 585-592.
Kuroda, Satoshi ; Furukawa, Koji ; Shiga, Tohru ; Ushikoshi, Satoshi ; Katoh, Chietsugu ; Aoki, Takeshi ; Ishikawa, Tatsuya ; Houkin, Kiyohiro ; Tamaki, Nagara ; Iwasaki, Yoshinobu ; Selman, Warren R. ; Day, Arthur L. ; Theodosopoulos, Philip V. ; Rigamonti, Daniele ; Spangler, Wendy ; Spetzler, Robert F. / Pretreatment and Posttreatment Evaluation of Hemodynamic and Metabolic Parameters in Intracranial Dural Arteriovenous Fistulae with Cortical Venous Reflux. In: Neurosurgery. 2004 ; Vol. 54, No. 3. pp. 585-592.
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T1 - Pretreatment and Posttreatment Evaluation of Hemodynamic and Metabolic Parameters in Intracranial Dural Arteriovenous Fistulae with Cortical Venous Reflux

AU - Kuroda, Satoshi

AU - Furukawa, Koji

AU - Shiga, Tohru

AU - Ushikoshi, Satoshi

AU - Katoh, Chietsugu

AU - Aoki, Takeshi

AU - Ishikawa, Tatsuya

AU - Houkin, Kiyohiro

AU - Tamaki, Nagara

AU - Iwasaki, Yoshinobu

AU - Selman, Warren R.

AU - Day, Arthur L.

AU - Theodosopoulos, Philip V.

AU - Rigamonti, Daniele

AU - Spangler, Wendy

AU - Spetzler, Robert F.

PY - 2004/3

Y1 - 2004/3

N2 - OBJECTIVE: Retrograde drainage into the cortical veins results in poor outcome in patients with an intracranial dural arteriovenous fistula. However, the pathophysiological features of dural arteriovenous fistulae remain obscure. This study aimed to clarify hemodynamic and metabolic conditions in these patients using positron emission tomography. METHODS: This study included eight patients with an intracranial dural arteriovenous fistula. All patients had cortical venous reflux, as demonstrated by angiography. Regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional cerebral metabolic rate for oxygen, and regional oxygen extraction fraction (rOEF) were measured before and after surgical or endovascular treatment using positron emission tomography. RESULTS: Pretreatment positron emission tomographic studies revealed that all patients had abnormal hemodynamic and metabolic parameters in the area that was drained by the involved cortical veins. A severe increase in rCBV was noted in seven of the eight patients. A significant decrease in rCBF also was observed in all eight patients. A negative correlation was observed between rCBF and rCBV. Three patients had an elevated rOEF. Oxygen metabolism was impaired in seven patients. All patients underwent successful treatment. Follow-up studies demonstrated significant improvements in rCBF, rCBV, and regional cerebral metabolic rate for oxygen. The improvement in regional cerebral metabolic rate for oxygen varied among the patients. Normalization of rOEF also was confirmed in three patients who had increased rOEF before the treatment. CONCLUSION: The present results suggest that hemodynamic and metabolic characteristics vary widely among patients with cortical venous reflux. It is essential to precisely evaluate hemodynamic and metabolic conditions to predict their outcomes and therapeutic effects.

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KW - Cerebral blood volume

KW - Cerebral oxygen metabolism

KW - Grading system

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KW - Positron emission tomography

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