Preterm birth and random plasma insulin levels at birth and in early childhood

Guoying Wang, Sara Divall, Sally Radovick, David M. Paige, Yi Ning, Zhu Chen, Yuelong Ji, Xiumei Hong, Sheila O. Walker, Deanna Caruso, Colleen Pearson, Mei Cheng Wang, Barry Zuckerman, Tina L Cheng, Xiaobin Wang

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: Although previous reports have linked preterm birth with insulin resistance in children and adults, it is not known whether altered insulin homeostasis is detectable at birth and tracks from birth through childhood. OBJECTIVE: To investigate whether preterm birth is associated with elevated plasma insulin levels at birth and whether this association persists into early childhood. DESIGN, SETTING, AND PARTICIPANTS: A prospective birth cohort of 1358 children recruited at birth from 1998 to 2010 and followed-up with prospectively from 2005 to 2012 at the Boston Medical Center in Massachusetts. MAIN OUTCOMES AND MEASURES: Random plasma insulin levels were measured at 2 time points: at birth (cord blood) and in early childhood (venous blood). The median age was 1.4 years (interquartile range [IQR], 0.8-3.3) among 4 gestational age groups: full term (≥39 wk), early term (37-38 wk), late preterm (34-36 wk), and early preterm (

Original languageEnglish (US)
Pages (from-to)587-596
Number of pages10
JournalJournal of the American Medical Association
Volume311
Issue number6
DOIs
StatePublished - 2014

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Premature Birth
Parturition
Insulin
Fetal Blood
Gestational Age
Insulin Resistance
Homeostasis
Age Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Preterm birth and random plasma insulin levels at birth and in early childhood. / Wang, Guoying; Divall, Sara; Radovick, Sally; Paige, David M.; Ning, Yi; Chen, Zhu; Ji, Yuelong; Hong, Xiumei; Walker, Sheila O.; Caruso, Deanna; Pearson, Colleen; Wang, Mei Cheng; Zuckerman, Barry; Cheng, Tina L; Wang, Xiaobin.

In: Journal of the American Medical Association, Vol. 311, No. 6, 2014, p. 587-596.

Research output: Contribution to journalArticle

Wang, Guoying ; Divall, Sara ; Radovick, Sally ; Paige, David M. ; Ning, Yi ; Chen, Zhu ; Ji, Yuelong ; Hong, Xiumei ; Walker, Sheila O. ; Caruso, Deanna ; Pearson, Colleen ; Wang, Mei Cheng ; Zuckerman, Barry ; Cheng, Tina L ; Wang, Xiaobin. / Preterm birth and random plasma insulin levels at birth and in early childhood. In: Journal of the American Medical Association. 2014 ; Vol. 311, No. 6. pp. 587-596.
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AU - Divall, Sara

AU - Radovick, Sally

AU - Paige, David M.

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AU - Chen, Zhu

AU - Ji, Yuelong

AU - Hong, Xiumei

AU - Walker, Sheila O.

AU - Caruso, Deanna

AU - Pearson, Colleen

AU - Wang, Mei Cheng

AU - Zuckerman, Barry

AU - Cheng, Tina L

AU - Wang, Xiaobin

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AB - IMPORTANCE: Although previous reports have linked preterm birth with insulin resistance in children and adults, it is not known whether altered insulin homeostasis is detectable at birth and tracks from birth through childhood. OBJECTIVE: To investigate whether preterm birth is associated with elevated plasma insulin levels at birth and whether this association persists into early childhood. DESIGN, SETTING, AND PARTICIPANTS: A prospective birth cohort of 1358 children recruited at birth from 1998 to 2010 and followed-up with prospectively from 2005 to 2012 at the Boston Medical Center in Massachusetts. MAIN OUTCOMES AND MEASURES: Random plasma insulin levels were measured at 2 time points: at birth (cord blood) and in early childhood (venous blood). The median age was 1.4 years (interquartile range [IQR], 0.8-3.3) among 4 gestational age groups: full term (≥39 wk), early term (37-38 wk), late preterm (34-36 wk), and early preterm (

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