Preterm birth and random plasma insulin levels at birth and in early childhood

Guoying Wang, Sara Divall, Sally Radovick, David Paige, Yi Ning, Zhu Chen, Yuelong Ji, Xiumei Hong, Sheila O. Walker, Deanna Caruso, Colleen Pearson, Mei Cheng Wang, Barry Zuckerman, Tina L. Cheng, Xiaobin Wang

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


IMPORTANCE: Although previous reports have linked preterm birth with insulin resistance in children and adults, it is not known whether altered insulin homeostasis is detectable at birth and tracks from birth through childhood. OBJECTIVE: To investigate whether preterm birth is associated with elevated plasma insulin levels at birth and whether this association persists into early childhood. DESIGN, SETTING, AND PARTICIPANTS: A prospective birth cohort of 1358 children recruited at birth from 1998 to 2010 and followed-up with prospectively from 2005 to 2012 at the Boston Medical Center in Massachusetts. MAIN OUTCOMES AND MEASURES: Random plasma insulin levels were measured at 2 time points: at birth (cord blood) and in early childhood (venous blood). The median age was 1.4 years (interquartile range [IQR], 0.8-3.3) among 4 gestational age groups: full term (≥39 wk), early term (37-38 wk), late preterm (34-36 wk), and early preterm (<34 wk). RESULTS: The geometric mean of insulin levels at birth were 9.2 μIU/mL (95%CI, 8.4-10.0) for full term; 10.3 μIU/mL (95%CI, 9.3-11.5) for early term; 13.2 μIU/mL (95%CI, 11.8-14.8) for late preterm; and 18.9 μIU/mL (95%CI, 16.6-21.4) for early preterm. In early childhood, these levels were 11.2 μIU/mL (95%CI, 10.3-12.0) for full term; 12.4 μIU/mL (95%CI, 11.3-13.6) for early term; 13.3 μIU/mL (95%CI, 11.9-14.8) for late preterm; and 14.6 μIU/mL (95%CI, 12.6-16.9) for early preterm. Insulin levels at birth were higher by 1.13-fold (95%CI, 0.97-1.28) for early term, 1.45-fold (95%CI, 1.25-1.65) for late preterm, and 2.05-fold (95%CI, 1.69-2.42) for early preterm than for those born full term. In early childhood, random plasma insulin levels were 1.12-fold (95%CI, 0.99-1.25) higher for early term, 1.19-fold (95%CI, 1.02-1.35) for late preterm, and 1.31-fold (95%CI, 1.10-1.52) for early preterm than those born full term. The association was attenuated after adjustment for postnatal weight gain and was not significant after adjustment for insulin levels at birth. Infants ranked in the top insulin tertile at birth were more likely to remain in the top tertile (41.2%) compared with children ranked in the lowest tertile (28.6%) in early childhood. CONCLUSIONS AND RELEVANCE: There was an inverse association between gestational age and elevated plasma insulin levels at birth and in early childhood. The implications for future development of insulin resistance and type 2 diabetes warrant further investigation.

Original languageEnglish (US)
Pages (from-to)587-596
Number of pages10
Issue number6
StatePublished - Feb 12 2014

ASJC Scopus subject areas

  • Medicine(all)


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