Presynaptic and postsynaptic D1 dopamine receptors in the nigrostriatal system of the rat brain: a quantitative autoradiographic study using the selective D1 antagonist [3H]SCH 23390

Francis M. Filloux, James K. Wamsley, Ted M. Dawson

Research output: Contribution to journalArticle

Abstract

Ibotenic acid lesions of the caudate-putamen in rat brain resulted in dramatic reductions in [3H]SCH 23390 binding in both the ipsilateral caudate-putamen and substantia nigra reticulata as assessed by quantitative autoradiography. Nigral ibotenic acid and 6-hydroxydopamine lesions did not significantly alter the binding in either structure. This indicates that D1 receptors in the caudate-putamen are postsynaptic on striatal neurons, while those in the substantia nigra reticulata are presynaptic on nerve terminals originating in the caudate-putamen.

Original languageEnglish (US)
Pages (from-to)205-209
Number of pages5
JournalBrain research
Volume408
Issue number1-2
DOIs
StatePublished - Apr 7 1987
Externally publishedYes

Keywords

  • 6-Hydroxydopamine
  • Autoradiography
  • D receptor, SCH-23390
  • Dopamine receptor
  • Ibotenic acid
  • Substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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