Abstract
Ibotenic acid lesions of the caudate-putamen in rat brain resulted in dramatic reductions in [3H]SCH 23390 binding in both the ipsilateral caudate-putamen and substantia nigra reticulata as assessed by quantitative autoradiography. Nigral ibotenic acid and 6-hydroxydopamine lesions did not significantly alter the binding in either structure. This indicates that D1 receptors in the caudate-putamen are postsynaptic on striatal neurons, while those in the substantia nigra reticulata are presynaptic on nerve terminals originating in the caudate-putamen.
Original language | English (US) |
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Pages (from-to) | 205-209 |
Number of pages | 5 |
Journal | Brain research |
Volume | 408 |
Issue number | 1-2 |
DOIs | |
State | Published - Apr 7 1987 |
Externally published | Yes |
Keywords
- 6-Hydroxydopamine
- Autoradiography
- D receptor, SCH-23390
- Dopamine receptor
- Ibotenic acid
- Substantia nigra
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology