Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys

Norman L. Letvin; John R. Mascola; Yue Sun; Darci A. Gorgone; Adam P. Buzby; Ling Xu; Zhi Yong Yang; Bimal Chakrabarti; Srinivas S. Rao; Jörn E. Schmitz; David C. Montefiori; Brianne R. Barker; Fred L. Bookstein; Gary J. Nabel

doi:10.1126/science.1124226

Preserved CD4⁺ central memory T cells and survival in vaccinated SIV-challenged monkeys

Norman L. Letvin, John R. Mascola, Yue Sun, Darci A. Gorgone, Adam P. Buzby, Ling Xu, Zhi Yong Yang, Bimal Chakrabarti, Srinivas S. Rao, Jörn E. Schmitz, David C. Montefiori, Brianne R. Barker, Fred L. Bookstein, Gary J. Nabel

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308 Scopus citations

Abstract

Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4⁺ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.

Original language	English (US)
Pages (from-to)	1530-1533
Number of pages	4
Journal	Science
Volume	312
Issue number	5779
DOIs	https://doi.org/10.1126/science.1124226
State	Published - Jun 9 2006
Externally published	Yes

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Letvin, N. L., Mascola, J. R., Sun, Y., Gorgone, D. A., Buzby, A. P., Xu, L., Yang, Z. Y., Chakrabarti, B., Rao, S. S., Schmitz, J. E., Montefiori, D. C., Barker, B. R., Bookstein, F. L., & Nabel, G. J. (2006). Preserved CD4⁺ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science, 312(5779), 1530-1533. https://doi.org/10.1126/science.1124226

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title = "Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys",

abstract = "Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.",

author = "Letvin, {Norman L.} and Mascola, {John R.} and Yue Sun and Gorgone, {Darci A.} and Buzby, {Adam P.} and Ling Xu and Yang, {Zhi Yong} and Bimal Chakrabarti and Rao, {Srinivas S.} and Schmitz, {J{\"o}rn E.} and Montefiori, {David C.} and Barker, {Brianne R.} and Bookstein, {Fred L.} and Nabel, {Gary J.}",

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AU - Letvin, Norman L.

AU - Mascola, John R.

AU - Sun, Yue

AU - Gorgone, Darci A.

AU - Buzby, Adam P.

AU - Xu, Ling

AU - Yang, Zhi Yong

AU - Chakrabarti, Bimal

AU - Rao, Srinivas S.

AU - Schmitz, Jörn E.

AU - Montefiori, David C.

AU - Barker, Brianne R.

AU - Bookstein, Fred L.

AU - Nabel, Gary J.

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AB - Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.

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Preserved CD4⁺ central memory T cells and survival in vaccinated SIV-challenged monkeys

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