Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys

Norman L. Letvin, John R. Mascola, Yue Sun, Darci A. Gorgone, Adam P. Buzby, Ling Xu, Zhi Yong Yang, Bimal Chakrabarti, Srinivas S. Rao, Jörn E. Schmitz, David C. Montefiori, Brianne R. Barker, Fred L. Bookstein, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.

Original languageEnglish (US)
Pages (from-to)1530-1533
Number of pages4
JournalScience
Volume312
Issue number5779
DOIs
StatePublished - Jun 9 2006
Externally publishedYes

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Simian Immunodeficiency Virus
Haplorhini
Cell Survival
T-Lymphocytes
AIDS Vaccines
Vaccines
Cellular Immunity
Survival
Viremia
Virus Diseases
Virus Replication
DNA Replication
Plasmids
Proteins

ASJC Scopus subject areas

  • General

Cite this

Letvin, N. L., Mascola, J. R., Sun, Y., Gorgone, D. A., Buzby, A. P., Xu, L., ... Nabel, G. J. (2006). Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science, 312(5779), 1530-1533. https://doi.org/10.1126/science.1124226

Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. / Letvin, Norman L.; Mascola, John R.; Sun, Yue; Gorgone, Darci A.; Buzby, Adam P.; Xu, Ling; Yang, Zhi Yong; Chakrabarti, Bimal; Rao, Srinivas S.; Schmitz, Jörn E.; Montefiori, David C.; Barker, Brianne R.; Bookstein, Fred L.; Nabel, Gary J.

In: Science, Vol. 312, No. 5779, 09.06.2006, p. 1530-1533.

Research output: Contribution to journalArticle

Letvin, NL, Mascola, JR, Sun, Y, Gorgone, DA, Buzby, AP, Xu, L, Yang, ZY, Chakrabarti, B, Rao, SS, Schmitz, JE, Montefiori, DC, Barker, BR, Bookstein, FL & Nabel, GJ 2006, 'Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys', Science, vol. 312, no. 5779, pp. 1530-1533. https://doi.org/10.1126/science.1124226
Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L et al. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science. 2006 Jun 9;312(5779):1530-1533. https://doi.org/10.1126/science.1124226
Letvin, Norman L. ; Mascola, John R. ; Sun, Yue ; Gorgone, Darci A. ; Buzby, Adam P. ; Xu, Ling ; Yang, Zhi Yong ; Chakrabarti, Bimal ; Rao, Srinivas S. ; Schmitz, Jörn E. ; Montefiori, David C. ; Barker, Brianne R. ; Bookstein, Fred L. ; Nabel, Gary J. / Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. In: Science. 2006 ; Vol. 312, No. 5779. pp. 1530-1533.
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