Preservation of memory CD4+ T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection

Sallia R. Permar, Helen H. Kang, Angela Carville, Andrew B. Wilks, Keith G. Mansfield, Srinivas S. Rao, Norman L. Letvin

Research output: Contribution to journalArticle

Abstract

Acute human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infection is associated with a massive depletion of memory CD4+ T lymphocytes in the gastrointestinal tract. To define the dynamics of the CD4+ T lymphocyte subpopulations in breast milk during acute HIV or SIV infection, lymphocyte populations were monitored in blood and milk of 4 Mamu-A*01+ rhesus monkeys after SIVmac251 inoculation. Strikingly, although the CD4+ T lymphocytes in blood were depleted during the peak of viremia, the milk CD4+ T lymphocyte counts remained unchanged, despite active virus replication in the breast milk compartment. Moreover, CD4+ memory T lymphocytes were preserved in breast milk during acute infection. CD4+ T lymphocytes in breast milk and other mucosal compartments of uninfected monkeys were similar in their memory phenotype, activation status, and chemokine (C-C motif) receptor 5 expression. Interestingly, the number and proportion of effector CD8+ T lymphocytes in milk were increased during acute SIV infection, suggesting effective control of virus-mediated CD4+ T lymphocyte destruction in the breast milk compartment

Original languageEnglish (US)
Pages (from-to)302-310
Number of pages9
JournalJournal of Infectious Diseases
Volume201
Issue number2
DOIs
StatePublished - Jan 15 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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