Presentation, diagnosis, pathophysiology, and treatment of the neurological features of sturge-weber syndrome

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Sturge-Weber syndrome (SWS) is a neurovascular disorder with a capillary malformation of the face (port-wine birthmark), a capillary-venous malformation in the eye, and a capillary-venous malformation in the brain (leptomeningeal angioma). Although SWS is a congenital disorder usually presenting in infancy, occasionally neurological symptoms first present in adulthood and most affected individuals do survive into adulthood with varying degrees of neurological impairment including epilepsy, hemiparesis, visual field deficits, and cognitive impairments ranging from mild learning disabilities to severe deficits. SWS is a multisystem disorder that requires the neurologist to be aware of the possible endocrine, psychiatric, ophthalmologic, and other medical issues that can arise and impact the neurological status of these patients. Some of these clinical features have only recently been described. REVIEW SUMMARY: This review summarizes the neurological manifestations of SWS, discusses issues related to the diagnosis of brain involvement, relates major neuroimaging findings, briefly describes the current understanding of pathogenesis, and provides an overview of neurological treatment strategies. CONCLUSIONS: Recent clinical research has highlighted several novel and lesser-known aspects of this clinical syndrome including endocrine disorders. Functional imaging studies and clinical experience suggests that neurological progression results primarily from impaired blood flow and that prolonged seizures may contribute to this process. Treatment is largely symptomatic although aggressive efforts to prevent seizures and strokes, in young children especially, may impact outcome.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalNeurologist
Volume17
Issue number4
DOIs
StatePublished - Jul 2011

Fingerprint

Sturge-Weber Syndrome
Seizures
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Learning Disorders
Brain
Paresis
Wine
Therapeutics
Hemangioma
Neurologic Manifestations
Visual Fields
Neuroimaging
Psychiatry
Epilepsy
Stroke
Research
Capillary Malformations, Congenital, 1

Keywords

  • migraines
  • port-wine birthmark
  • seizures
  • stroke
  • Sturge-Weber syndrome

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Presentation, diagnosis, pathophysiology, and treatment of the neurological features of sturge-weber syndrome. / Comi, Anne Marie Spalding.

In: Neurologist, Vol. 17, No. 4, 07.2011, p. 179-184.

Research output: Contribution to journalArticle

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