TY - JOUR
T1 - Present Status of Chemotherapy for Tuberculosis
AU - Grosset, Jacques H.
PY - 1989/3
Y1 - 1989/3
N2 - For the treatment of smear-positive pulmonary tuberculosis, short-course chemotherapy of 6 months’ duration (with the four-drug combination of isoniazid, rifampin, pyrazinamide, and either ethambutol or streptomycin given daily for a 2-month initial intensive phase followed by a 4-month daily continuation phase with isoniazid and rifampin) is as effective and as acceptable as the standard 9-month daily course of therapy (with isoniazid, rifampin, and ethambutol given for a 2-month initial intensive phase followed by a 7-month daily continuation phase with isoniazid and rifampin). The duration of short- course chemotherapy cannot be further reduced for smear-negative and culture-positive or smear-negative and culture-negative pulmonary tuberculosis or for extrapulmonary tuberculosis. Isoniazid has been demonstrated to be active as prophylactic therapy for tuberculosis at a daily dose of 300 mg (5-10 mg/kg in children) for 6-12 months. Prophylaxis of 2 months’ duration with daily administration of isoniazid, rifampin, and pyrazinamide may be as effective as prophylactic therapy with isoniazid of 12 months’ duration.
AB - For the treatment of smear-positive pulmonary tuberculosis, short-course chemotherapy of 6 months’ duration (with the four-drug combination of isoniazid, rifampin, pyrazinamide, and either ethambutol or streptomycin given daily for a 2-month initial intensive phase followed by a 4-month daily continuation phase with isoniazid and rifampin) is as effective and as acceptable as the standard 9-month daily course of therapy (with isoniazid, rifampin, and ethambutol given for a 2-month initial intensive phase followed by a 7-month daily continuation phase with isoniazid and rifampin). The duration of short- course chemotherapy cannot be further reduced for smear-negative and culture-positive or smear-negative and culture-negative pulmonary tuberculosis or for extrapulmonary tuberculosis. Isoniazid has been demonstrated to be active as prophylactic therapy for tuberculosis at a daily dose of 300 mg (5-10 mg/kg in children) for 6-12 months. Prophylaxis of 2 months’ duration with daily administration of isoniazid, rifampin, and pyrazinamide may be as effective as prophylactic therapy with isoniazid of 12 months’ duration.
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U2 - 10.1093/clinids/11.Supplement_2.S347
DO - 10.1093/clinids/11.Supplement_2.S347
M3 - Article
C2 - 2652251
AN - SCOPUS:0024637416
SN - 0162-0886
VL - 11
SP - S347-S352
JO - Reviews of infectious diseases
JF - Reviews of infectious diseases
ER -