Present and future therapies of hepatitis B: From discovery to cure

T. Jake Liang; Timothy M. Block; Brian J. McMahon; Marc G. Ghany; Stephan Urban; Ju Tao Guo; Stephen Locarnini; Fabien Zoulim; Kyong Mi Chang; Anna S. Lok

doi:10.1002/hep.28025

Present and future therapies of hepatitis B: From discovery to cure

T. Jake Liang, Timothy M. Block, Brian J. McMahon, Marc G. Ghany, Stephan Urban, Ju Tao Guo, Stephen Locarnini, Fabien Zoulim, Kyong Mi Chang, Anna S. Lok

Research output: Contribution to journal › Article › peer-review

189 Scopus citations

Abstract

Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline. Conclusion: With growing interest in developing and efforts to develop more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.

Original language	English (US)
Pages (from-to)	1893-1908
Number of pages	16
Journal	Hepatology
Volume	62
Issue number	6
DOIs	https://doi.org/10.1002/hep.28025
State	Published - Dec 1 2015
Externally published	Yes

ASJC Scopus subject areas

Hepatology

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10.1002/hep.28025

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title = "Present and future therapies of hepatitis B: From discovery to cure",

abstract = "Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline. Conclusion: With growing interest in developing and efforts to develop more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.",

author = "Liang, {T. Jake} and Block, {Timothy M.} and McMahon, {Brian J.} and Ghany, {Marc G.} and Stephan Urban and Guo, {Ju Tao} and Stephen Locarnini and Fabien Zoulim and Chang, {Kyong Mi} and Lok, {Anna S.}",

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T1 - Present and future therapies of hepatitis B

T2 - From discovery to cure

AU - Liang, T. Jake

AU - Block, Timothy M.

AU - McMahon, Brian J.

AU - Ghany, Marc G.

AU - Urban, Stephan

AU - Guo, Ju Tao

AU - Locarnini, Stephen

AU - Zoulim, Fabien

AU - Chang, Kyong Mi

AU - Lok, Anna S.

PY - 2015/12/1

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AB - Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline. Conclusion: With growing interest in developing and efforts to develop more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.

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Present and future therapies of hepatitis B: From discovery to cure

Abstract

ASJC Scopus subject areas

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