Presencia de placas coronarias vulnerables en mujeres de mediana edad que sufrieron muerte cerebral

Translated title of the contribution: Presence of vulnerable coronary plaques in middle-aged women who suffered brain death

Enrique Gurfinkel, Carlos Vigliano, Patricia Cabeza Meckert, Alejandro Bertolotti, Roberto Favaloro, Juan Carlos Troncoso, Rubén Laguens

Research output: Contribution to journalArticle

Abstract

Background: The presence of vulnerable plaques is a common finding in the coronary arteries of previously asymptomatic men who died suddenly or due to an acute coronary syndrome. The prevalence and the characteristics of these plaques in middle-aged women are still unknown. Objective: To evaluate the presence of vulnerable coronary plaques in middle-aged women who suffered brain death. Material and Methods: From a total of 652 hearts from transplant donors collected between 1996 and 2007, we selected those from apparently healthy individuals older than 40 years old who died of head trauma or stroke. From a total of 160 elegible organs, the coronary arteries of 70 female hearts were examined by serial sectioning at 3-mm intervals. The areas with luminal narrowing were processed for subsequent histological and immuhistochemical studies. Plaques were classified according to the American Heart Association (AHA) report. Results: Mean age was 50.7±5.7 years. The degree of average vascular obstruction was 28.66%±17.35%. A total of 41 hearts had no advanced coronary atherosclerotic lesions (Type I, II, and III of the AHA classification). In the remaining 29 hearts we found 58 plaques considered high-risk lesions (AHA type IV, V and VI). These plaques were less frequent in women than in men (p<0,001) and were associated with higher heart weight (OR 1.02, 95% CI 1.01-1.04; p<0.001) and with age (OR 1.11, 95% CI 1.01-1.23; p=0.038). No significant association with the cause of death was found (p = 0.065). Conclusions: In 41.4% of women who suffered brain death, we found vulnerable plaques in the coronary arteries that were not associated with significant lumen obstructions. This series suggests the presence of 0.82 coronary lesions which are prone to develop thrombosis in apparently healthy middleaged women who suffered brain death.

Translated title of the contributionPresence of vulnerable coronary plaques in middle-aged women who suffered brain death
Original languageSpanish
Pages (from-to)478-486
Number of pages9
JournalRevista Argentina de Cardiologia
Volume77
Issue number6
StatePublished - Nov 1 2009
Externally publishedYes

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Epidemiology
  • Pathology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Gurfinkel, E., Vigliano, C., Cabeza Meckert, P., Bertolotti, A., Favaloro, R., Troncoso, J. C., & Laguens, R. (2009). Presencia de placas coronarias vulnerables en mujeres de mediana edad que sufrieron muerte cerebral. Revista Argentina de Cardiologia, 77(6), 478-486.