Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia

Mitsuro Kanda, Hanno Matthaei, Jian Wu, Seung Mo Hong, Jun Yu, Michael Borges, Ralph H. Hruban, Anirban Maitra, Kenneth Kinzler, Bert Vogelstein, Michael Goggins

Research output: Contribution to journalArticlepeer-review

Abstract

More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasmsthe most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.

Original languageEnglish (US)
Pages (from-to)730-733.e9
JournalGastroenterology
Volume142
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Neoplasm
  • Pancreatic Cancer
  • Transformation
  • Tumorigenesis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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