Presence of nicotinic acetylcholine receptors in cat carotid body afferent system

MacHiko Shirahata, Yumiko Ishizawa, Maria Rudisill, Brian Schofield, Robert S. Fitzgerald

Research output: Contribution to journalArticlepeer-review

Abstract

With immunocytochemical techniques using a monoclonal antibody for α7 subunits of neuronal nicotinic acetylcholine receptors, we have found these subunits to be exclusively expressed in nerve fibers in the carotid body. Double-immunostaining showed that α7 subunit-positive nerve endings enveloped tyrosine hydroxylase-positive glomus cells. Some carotid sinus nerve fibers and tyrosine hydroxylase-positive petrosal ganglion neurons also expressed α7 subunits. These data support a role for acetylcholine in carotid body neurotransmission.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalBrain research
Volume814
Issue number1-2
DOIs
StatePublished - Dec 14 1998

Keywords

  • Antibody
  • Chemoreceptor
  • Immunocytochemistry
  • Tyrosine hydroxylase
  • α7 subunit

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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