Presence of Antibodies to Simian Virus 40 (SV40) T Antigen in Rhesus Monkeys Infected Experimentally or Naturally with SV40

K. V. Shah, D. M. Hess

Research output: Contribution to journalArticlepeer-review

Abstract

All of 16 rhesus infected with SV40 by i.n., s.c., or i.g. inoculation developed neutralizing antibodies by the third week after inoculation. All of 10 animals infected by s.c. or i.g. route and a majority of those by the i.n. route were viremic. Viremia titers were higher in the group inoculated s.c. The T antibodies developed in all except two in the i.n. inoculated group. The T antibodies appeared earlier, reached higher peaks, and persisted longer after s.c. inoculation as compared to after i.n. inoculation. The T antibodies were detected in a proportion of naturally infected rhesus. This proportion was highest (85%) in 1-2 year old rhesus and declined with increase in age of donor.

Original languageEnglish (US)
Pages (from-to)480-485
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume128
Issue number2
DOIs
StatePublished - Jun 1968

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Presence of Antibodies to Simian Virus 40 (SV40) T Antigen in Rhesus Monkeys Infected Experimentally or Naturally with SV40'. Together they form a unique fingerprint.

Cite this