@article{829651ee42a24a37b1a5d48d7faabe76,
title = "Presence of a bent helix in fragments of kinetoplast DNA minicircles from several trypanosomatid species",
abstract = "Some restriction fragments of kinetoplast minicircles from several trypanosomatid species (Leishmania tarentolae, Trypanosoma brucei, T. equiperdum, Herpetomonas muscarum, Crithidia fasciculata, but not T. cruzi) migrate anomalously on polyacrylamide gels. This behavior is probably due to a natural curvature of the helix. Bent helices appear to be a common property of kinetoplast minicircles, and may be important for minicircle function. In the case of T. equiperdum, we present evidence that each minicircle has a single bent region which resides in or near the 'conserved sequence'.",
keywords = "Bent helix, Kinetoplast DNA, Minicircle, Trypanosomatid",
author = "Ntambi, {James M.} and Marini, {Joan C.} and Bangs, {James D.} and Hajduk, {Stephen L.} and Jimenez, {Hector E.} and Kitchin, {Peter A.} and Klein, {Viiu A.} and Ryan, {Kathleen A.} and Englund, {Paul T.}",
note = "Funding Information: Donald M. Crothers and Larry Simpson for unpublished manuscripts. This research was supported in part by NIH Grant GM-27608 and in part by the Biomedical Sciences component of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. JMN and HEJ were supported by the Fulbright Foundation, JCM was supported by Medical Scientist Training Grant GM7309, JDB by NIH Training Grant GMO7445, and SLH by a fellowship from the Rockefeller Foundation. PTE is a Burroughs Wellcome Scholar in Molecular Parasitology.",
year = "1984",
month = jul,
doi = "10.1016/0166-6851(84)90084-7",
language = "English (US)",
volume = "12",
pages = "273--286",
journal = "Molecular and Biochemical Parasitology",
issn = "0166-6851",
publisher = "Elsevier",
number = "3",
}