Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

R. Glenn Smith, Y. Kay Henry, Mark P. Mattson, Stanley H. Appel

Research output: Contribution to journalArticlepeer-review

Abstract

A marker of lipid peroxidation 4-hydroxynonenal (HNE) was elevated in the cerebrospinal fluid (CSF) of a patient with sporadic amyotrophic lateral sclerosis (sALS) compared with that of most patients with other neurological diseases. Such elevations of HNE were sufficient to kill cyclic adenosine monophosphate (cAMP)-differentiated motor neuron hybrid cells in vitro, and anti-oxidants prevented this HNE-dependent cell death. These data suggest that oxidative stress and lipid peroxidation are associated with and may promote motor neuron degeneration in sALS.

Original languageEnglish (US)
Pages (from-to)696-699
Number of pages4
JournalAnnals of Neurology
Volume44
Issue number4
DOIs
StatePublished - Oct 1998
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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