Immunoglobulin E (γE) was detected in nasal washings and sputum obtained from some asthmatic patients. The measurement of γE concentration was not affected by the presence of enzymes or insoluble components of the exocrine fluids. Quantitatively, the γE γG concentration ratios in the specimens were usually higher than those in sera of the same patients. The results suggested the possibility that locally formed γE may be secreted, at least in part, into nasal fluids and sputum.
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