Presence in human urine of a new N-nitroso compound, N-nitrosothiazolidine 4-carboxylic acid

Hiroshi Ohshima, Marlin Friesen, Ian O'Neill, Helmut Bartsch

Research output: Contribution to journalArticle

Abstract

Urine samples collected in several countries from human subjects showed the presence of a number of N-nitroso compounds not previously identified. By several separative procedures and by comparison with authentic material, the major unknown N-nitroso compound was shown to be N-nitrosothiazolidine 4-carboxylic acid (NTCA). Although its origin in human urine is unknown, thiazolidine 4-carboxylic acid, the easily nitrosatable amine precursor, can be formed by reaction of formaldehyde with cysteine in vivo and in vitro. Thus measuring NTCA excreted in the urine may allow monitoring exposure of human subjects to precursors like formaldehyde and NO3- NO2-.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalCancer Letters
Volume20
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

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Nitroso Compounds
Urine
Formaldehyde
Carboxylic Acids
Amines
Cysteine
N-nitrosothiazolidine-4-carboxylic acid

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Presence in human urine of a new N-nitroso compound, N-nitrosothiazolidine 4-carboxylic acid. / Ohshima, Hiroshi; Friesen, Marlin; O'Neill, Ian; Bartsch, Helmut.

In: Cancer Letters, Vol. 20, No. 2, 1983, p. 183-190.

Research output: Contribution to journalArticle

Ohshima, Hiroshi ; Friesen, Marlin ; O'Neill, Ian ; Bartsch, Helmut. / Presence in human urine of a new N-nitroso compound, N-nitrosothiazolidine 4-carboxylic acid. In: Cancer Letters. 1983 ; Vol. 20, No. 2. pp. 183-190.
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