Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of U.S. Registry and Pharmacy fill records

Luke S. Vest, Nagaraju Sarabu, Farrukh M. Koraishy, Minh Tri Nguyen, Meyeon Park, Ngan N. Lam, Mark A. Schnitzler, David Axelrod, Chi Yuan Hsu, Amit X. Garg, Dorry L. Segev, Allan B. Massie, Gregory P. Hess, Bertram L. Kasiske, Krista L. Lentine

Research output: Contribution to journalArticlepeer-review

Abstract

We examined a novel database linking national donor registry identifiers to records from a US pharmaceutical claims warehouse (2007-2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0-14 days, 15-182 days, and 183-365 days. Associations of opioid and NSAID prescription fills with baseline factors were examined by logistic regression (adjusted odds ratio, LCLaORUCL). Among 23,565 donors, opioid prescriptions were highest during days 0-14 (36.6%), but 12.6% of donors filled opioids during days 183-365. NSAID prescriptions rose from 0.5% during days 0-14 to 3.3% during days 183-365. Women filled opioids more commonly than men, and black donors filled both opioids and NSAIDs more commonly than white donors. After covariate adjustment, significant correlates of opioid prescription fills during days 183-365 included obesity (aOR,1.241.381.53), less than college education (aOR,1.191.311.43), smoking (aOR,1.331.451.58), and nephrectomy complications (aOR,1.111.291.49). NSAID prescription fills in year 1 were not associated with differences in estimated glomerular filtration rate, incidence of proteinuria or new-onset hypertension at the first and second year postdonation. Prescription fills for opioids and NSAIDs for LKDs varied with demographic and clinic traits. Future work should examine longer-term outcome implications to help inform safe analgesic regimen choices after donation.

Original languageEnglish (US)
Article numbere14000
JournalClinical Transplantation
Volume34
Issue number8
DOIs
StatePublished - Aug 1 2020

Keywords

  • donors and donation
  • epidemiology
  • living kidney donor
  • pain management
  • pharmacy records
  • registries

ASJC Scopus subject areas

  • Transplantation

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