Prescription medications: A modifiable contributor to obesity

Lawrence J Cheskin, Susan J. Bartlett, Roberto Zayas, Charles H. Twilley, David B. Allison, Carlo Contoreggi

Research output: Contribution to journalArticle

Abstract

Background. While usually not the only factor in obese patients, prescription medications, which may increase appetite or body weight, can be important in some individuals. The cause of weight gain in such cases may go unrecognized or lead to cessation of medication with or without the practitioner's knowledge or approval. Methods. We found illustrative cases among patients treated at the Johns Hopkins Weight Management Center, searched MEDLINE and the Micromedex Drug Information database, and organized this information by drug mechanism and indications for use. Results. Most reports of medication-induced weight gain are anecdotal or gleaned from clinical trials. Notable offenders include hormones (especially corticosteroids and insulinotropic agents), and psychoactive medications (especially tricyclic antidepressants, lithium, and some antipsychotics). Conclusions. Medication-related increases in appetite and body weight are under-recognized and cause noncompliance with pharmacotherapy. A high index of awareness of the known mechanisms by which medications can lead to weight gain has the potential to prevent most medication-related contributions to weight gain and obesity.

Original languageEnglish (US)
Pages (from-to)898-904
Number of pages7
JournalSouthern Medical Journal
Volume92
Issue number9
StatePublished - Sep 1999

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Weight Gain
Prescriptions
Obesity
Appetite
Body Weight
Pharmaceutical Databases
Tricyclic Antidepressive Agents
Psychotropic Drugs
Lithium
MEDLINE
Antipsychotic Agents
Adrenal Cortex Hormones
Clinical Trials
Hormones
Weights and Measures
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cheskin, L. J., Bartlett, S. J., Zayas, R., Twilley, C. H., Allison, D. B., & Contoreggi, C. (1999). Prescription medications: A modifiable contributor to obesity. Southern Medical Journal, 92(9), 898-904.

Prescription medications : A modifiable contributor to obesity. / Cheskin, Lawrence J; Bartlett, Susan J.; Zayas, Roberto; Twilley, Charles H.; Allison, David B.; Contoreggi, Carlo.

In: Southern Medical Journal, Vol. 92, No. 9, 09.1999, p. 898-904.

Research output: Contribution to journalArticle

Cheskin, LJ, Bartlett, SJ, Zayas, R, Twilley, CH, Allison, DB & Contoreggi, C 1999, 'Prescription medications: A modifiable contributor to obesity', Southern Medical Journal, vol. 92, no. 9, pp. 898-904.
Cheskin LJ, Bartlett SJ, Zayas R, Twilley CH, Allison DB, Contoreggi C. Prescription medications: A modifiable contributor to obesity. Southern Medical Journal. 1999 Sep;92(9):898-904.
Cheskin, Lawrence J ; Bartlett, Susan J. ; Zayas, Roberto ; Twilley, Charles H. ; Allison, David B. ; Contoreggi, Carlo. / Prescription medications : A modifiable contributor to obesity. In: Southern Medical Journal. 1999 ; Vol. 92, No. 9. pp. 898-904.
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