Prescribing patterns of low doses of antipsychotic medications in older Asian patients with schizophrenia, 2001-2009

Yu Tao Xiang, Faith Dickerson, Julie Kreyenbuhl, Gabor S. Ungvari, Chuan Yue Wang, Tian Mei Si, Edwin H M Lee, Yan Ling He, Helen F K Chiu, Kelly Y C Lai, Naotaka Shinfuku, Shu Yu Yang, Mian Yoon Chong, Ee Heok Kua, Senta Fujii, Kang Sim, Michael K H Yong, Jitendra K. Trivedi, Eun Kee Chung, Pichet UdomratnKok Yoon Chee, Norman Sartorius, Chay Hoon Tan

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study examined the use of low doses of antipsychotic medications (300mg/day CPZeq or less) in older Asian patients with schizophrenia and its demographic and clinical correlates. Methods: Information on hospitalized patients with schizophrenia, aged 55 years or older, was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001-2009). Data on 1,452 patients in eight Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India, and Malaysia were analyzed. Sociodemographic and clinical characteristics and antipsychotic prescriptions were recorded using a standardized protocol and data collection procedure. Results: The prescription frequency for low doses of antipsychotic medications was 40.9% in the pooled sample. Multiple logistic regression analysis of the whole sample showed that patients on low doses of antipsychotic medications were more likely to be female, have an older age, a shorter length of illness, and less positive symptoms. Of patients in the six countries and territories that participated in all the surveys between 2001 and 2009, those in Japan were less likely to receive low doses of antipsychotics. Conclusion: Low doses of antipsychotic medications were only applied in less than half of older Asian patients with schizophrenia.

Original languageEnglish (US)
Pages (from-to)1002-1008
Number of pages7
JournalInternational Psychogeriatrics
Volume24
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Asia
  • low doses
  • older patients
  • prescription patterns
  • schizophrenia

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Gerontology
  • Clinical Psychology

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