Preproenkephalin mRNA expression in nucleus caudalis neurons is enhanced by trigeminal stimulation

Toshikazu Nishimori, M. Gabriella Buzzi, Michael A. Moskowitz, George R. Uhl

Research output: Contribution to journalArticle

Abstract

Electrical stimulation of trigeminal afferents increases expression of preproenkephalin mRNA in neurons of laminae I and II of the trigeminal nucleus caudalis in animals sacrificed 6 hours after the end of stimulation. More neurons express, and positive cells express at higher levels. These neurons thus express the mRNA corresponding to a major pain-modulating neurotransmitter gene with significant input-related plasticity.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalMolecular Brain Research
Volume6
Issue number2-3
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Nucleus caudalis
  • Preproenkephalin mRNA
  • Trigeminal afferent

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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