Abstract
We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1-6 superparamagnetic iron oxide crystal per vesicle. The T1 and T2 relaxivities were 3 and 240 s-1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2 ± 13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.
Original language | English (US) |
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Pages (from-to) | 204-209 |
Number of pages | 6 |
Journal | Journal of Magnetism and Magnetic Materials |
Volume | 194 |
Issue number | 1 |
DOIs | |
State | Published - Apr 1999 |
Externally published | Yes |
Event | Proceedings of 1998 2nd International Conference on Scientific and Clinical Applications of Magnetic Carriers - Cleveland, OH, USA Duration: May 28 1998 → May 30 1998 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics