Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent

Jeff W Bulte, Marcel De Cuyper, Daryl Despres, Joseph A. Frank

Research output: Contribution to journalArticle

Abstract

We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1-6 superparamagnetic iron oxide crystal per vesicle. The T1 and T2 relaxivities were 3 and 240 s-1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2 ± 13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.

Original languageEnglish (US)
Pages (from-to)204-209
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume194
Issue number1
DOIs
StatePublished - Apr 1999
Externally publishedYes

Fingerprint

bone marrow
clearances
iron oxides
half life
Contrast Media
Polyethylene glycols
rats
blood
preparation
crystals
Iron oxides
Rats
Bone
Blood
Imaging techniques
Crystals

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent. / Bulte, Jeff W; Cuyper, Marcel De; Despres, Daryl; Frank, Joseph A.

In: Journal of Magnetism and Magnetic Materials, Vol. 194, No. 1, 04.1999, p. 204-209.

Research output: Contribution to journalArticle

Bulte, Jeff W ; Cuyper, Marcel De ; Despres, Daryl ; Frank, Joseph A. / Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent. In: Journal of Magnetism and Magnetic Materials. 1999 ; Vol. 194, No. 1. pp. 204-209.
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