Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent

Jeff W.M. Bulte; Marcel De Cuyper; Daryl Despres; Joseph A. Frank

doi:10.1016/S0304-8853(98)00556-3

Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent

Jeff W.M. Bulte, Marcel De Cuyper, Daryl Despres, Joseph A. Frank

Research output: Contribution to journal › Conference article › peer-review

94 Scopus citations

Abstract

We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1-6 superparamagnetic iron oxide crystal per vesicle. The T1 and T2 relaxivities were 3 and 240 s^-1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2 ± 13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.

Original language	English (US)
Pages (from-to)	204-209
Number of pages	6
Journal	Journal of Magnetism and Magnetic Materials
Volume	194
Issue number	1
DOIs	https://doi.org/10.1016/S0304-8853(98)00556-3
State	Published - Apr 1999
Externally published	Yes
Event	Proceedings of 1998 2nd International Conference on Scientific and Clinical Applications of Magnetic Carriers - Cleveland, OH, USA Duration: May 28 1998 → May 30 1998

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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title = "Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent",

abstract = "We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1-6 superparamagnetic iron oxide crystal per vesicle. The T1 and T2 relaxivities were 3 and 240 s-1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2 ± 13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.",

author = "Bulte, {Jeff W.M.} and Cuyper, {Marcel De} and Daryl Despres and Frank, {Joseph A.}",

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AU - Bulte, Jeff W.M.

AU - Cuyper, Marcel De

AU - Despres, Daryl

AU - Frank, Joseph A.

PY - 1999/4

Y1 - 1999/4

N2 - We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1-6 superparamagnetic iron oxide crystal per vesicle. The T1 and T2 relaxivities were 3 and 240 s-1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2 ± 13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.

AB - We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1-6 superparamagnetic iron oxide crystal per vesicle. The T1 and T2 relaxivities were 3 and 240 s-1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2 ± 13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.

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DO - 10.1016/S0304-8853(98)00556-3

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VL - 194

SP - 204

EP - 209

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 1

T2 - Proceedings of 1998 2nd International Conference on Scientific and Clinical Applications of Magnetic Carriers

Y2 - 28 May 1998 through 30 May 1998

ER -

Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent

Abstract

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