Preparation of [11C]- and [125I]IMB: a dopamine D-2 receptor antagonist

Alan A. Wilson, Robert F. Dannals, Hayden T. Ravert, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

A new dopamine D-2 receptor ligand, N-[2-(N′-4-iodobenzyl-N′-methyl)aminoethyl]-5-chloro-2-metho xy-4-(methylamino)benzamide (IMB) was synthesized and labelled with 11C and 125I at high specific activities. Both radiotracers were prepared by alkylation reactions with [11C]iodomethane and [125I]4-iodobenzyl bromide and appropriate 2° amine precursors. Isolated radiochemical yields of 12-20% for [11C]IMB and 35-50% for [125I]IMB were achieved in 24 and 130-150 min respectively. [11C]IMB and [123I]IMB may prove suitable for a direct comparison of PET and SPECT in the localization and quantification of neuroreceptors.

Original languageEnglish (US)
Pages (from-to)369-373
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume40
Issue number5
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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