A monoclonal antibody, elicited by a transition-state analogue, acted as an enzymelike catalyst for the formation of carbon-carbon bond. The generation of carboanion by the action of abzyme and the internal nucleophilic attack on the activated functional group, such as the carbonyl and/or the imine group with a fluoroalkyl group, producing the corresponding δ-lactones, are described.
- Carbon-carbon bond formation
ASJC Scopus subject areas
- Process Chemistry and Technology