Preparation of heterocyclic compounds via carbon-carbon bond formation catalyzed by an antibody

Tomoya Kitazume, Takashi Tsukamoto, Kouichi Murata, Koutaro Yoshimura

Research output: Contribution to journalArticlepeer-review

Abstract

A monoclonal antibody, elicited by a transition-state analogue, acted as an enzymelike catalyst for the formation of carbon-carbon bond. The generation of carboanion by the action of abzyme and the internal nucleophilic attack on the activated functional group, such as the carbonyl and/or the imine group with a fluoroalkyl group, producing the corresponding δ-lactones, are described.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Molecular Catalysis B: Enzymatic
Volume2
Issue number1
DOIs
StatePublished - Sep 30 1996
Externally publishedYes

Keywords

  • Abzyme
  • Antibody
  • Carbon-carbon bond formation

ASJC Scopus subject areas

  • Catalysis
  • Bioengineering
  • Biochemistry
  • Process Chemistry and Technology

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