Preparation of heterocyclic compounds via carbon-carbon bond formation catalyzed by an antibody

Tomoya Kitazume; Takashi Tsukamoto; Kouichi Murata; Koutaro Yoshimura

doi:10.1016/1381-1177(95)00024-0

Preparation of heterocyclic compounds via carbon-carbon bond formation catalyzed by an antibody

Tomoya Kitazume, Takashi Tsukamoto, Kouichi Murata, Koutaro Yoshimura

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A monoclonal antibody, elicited by a transition-state analogue, acted as an enzymelike catalyst for the formation of carbon-carbon bond. The generation of carboanion by the action of abzyme and the internal nucleophilic attack on the activated functional group, such as the carbonyl and/or the imine group with a fluoroalkyl group, producing the corresponding δ-lactones, are described.

Original language	English (US)
Pages (from-to)	27-31
Number of pages	5
Journal	Journal of Molecular Catalysis B: Enzymatic
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/1381-1177(95)00024-0
State	Published - Sep 30 1996
Externally published	Yes

Keywords

Abzyme
Antibody
Carbon-carbon bond formation

ASJC Scopus subject areas

Catalysis
Bioengineering
Biochemistry
Process Chemistry and Technology

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10.1016/1381-1177(95)00024-0

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abstract = "A monoclonal antibody, elicited by a transition-state analogue, acted as an enzymelike catalyst for the formation of carbon-carbon bond. The generation of carboanion by the action of abzyme and the internal nucleophilic attack on the activated functional group, such as the carbonyl and/or the imine group with a fluoroalkyl group, producing the corresponding δ-lactones, are described.",

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doi = "10.1016/1381-1177(95)00024-0",

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T1 - Preparation of heterocyclic compounds via carbon-carbon bond formation catalyzed by an antibody

AU - Kitazume, Tomoya

AU - Tsukamoto, Takashi

AU - Murata, Kouichi

AU - Yoshimura, Koutaro

PY - 1996/9/30

Y1 - 1996/9/30

N2 - A monoclonal antibody, elicited by a transition-state analogue, acted as an enzymelike catalyst for the formation of carbon-carbon bond. The generation of carboanion by the action of abzyme and the internal nucleophilic attack on the activated functional group, such as the carbonyl and/or the imine group with a fluoroalkyl group, producing the corresponding δ-lactones, are described.

AB - A monoclonal antibody, elicited by a transition-state analogue, acted as an enzymelike catalyst for the formation of carbon-carbon bond. The generation of carboanion by the action of abzyme and the internal nucleophilic attack on the activated functional group, such as the carbonyl and/or the imine group with a fluoroalkyl group, producing the corresponding δ-lactones, are described.

KW - Abzyme

KW - Antibody

KW - Carbon-carbon bond formation

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JF - Journal of Molecular Catalysis - B Enzymatic

IS - 1

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Preparation of heterocyclic compounds via carbon-carbon bond formation catalyzed by an antibody

Abstract

Keywords

ASJC Scopus subject areas

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