Preparation of deuterated arachidonic acid

D. F. Taber, M. A. Phillips, W. C. Hubbard

Research output: Contribution to journalArticlepeer-review

Abstract

Arachidonic acid is transformed in vivo to a wide variety of oxygenated metabolites. The limiting factor in the quantitation of these metabolites by GC/MS using selected ion monitoring (SIM) is the availability of suitable stable-isotope labelled internal standards. We report a convenient procedure for the preparation of 2H8-arachidonic acid, from which the desired deuterated metabolite standards can be produced by a combination of chemical and biological procedures.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalProstaglandins
Volume22
Issue number3
DOIs
StatePublished - Sep 1981

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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