Formylation of difluorinated Reformatsky reagents derived from chlorodifluoroacetic acid derivatives provided β,β-difluorinated N,O-acetals, which were easily converted into the corresponding ethyl hemiacetals. These compounds were found to be effective aldehyde equivalents and reacted with active methylene compounds, nitromethane, or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides in good yields.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - 1993|
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