Preparation and reaction of difluorinated malonaldehydic acid derivatives: A new route to functionalized α,α-difluorinated esters and amides

Takashi Tsukamoto, Tomoya Kitazume

Research output: Contribution to journalArticlepeer-review

Abstract

Formylation of difluorinated Reformatsky reagents derived from chlorodifluoroacetic acid derivatives provided β,β-difluorinated N,O-acetals, which were easily converted into the corresponding ethyl hemiacetals. These compounds were found to be effective aldehyde equivalents and reacted with active methylene compounds, nitromethane, or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides in good yields.

Original languageEnglish (US)
Pages (from-to)1177-1181
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number10
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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