Preparation and immunosuppressive potency of equine anti human thymocyte membrane IgG

A. G. Diethelm, L. M. Chambers, C. M. Balch, S. J. Phillips

Research output: Contribution to journalArticlepeer-review

Abstract

Anti human thymocyte cell membrane antibody prepared by hyperimmunization of the horse produced an antiserum capable of prolonging skin allografts in the rhesus monkey for an average of 26 days. Lymphocyte depletion was present in paracortical areas of mesenteric lymph nodes of these animals after 28 days of treatment; the intravenous administration was tolerated without ill effects. Immunofluorescent studies identified both broad specificity antibodies reacting with numerous human cell types as well as thymus dependent (T) cell antibodies reactive with human thymocytes and peripheral T cells.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalPostgraduate Medical Journal
Volume52
Issue numberSup.5
StatePublished - Dec 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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