Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective α(1a)-receptor

James C. Barrow, Kristen L. Glass, Harold G. Selnick, Roger M. Freidinger, Raymond S.L. Chang, Stacey S. O'Malley, Carla Woyden

Research output: Contribution to journalArticlepeer-review

Abstract

Several 1,3-diaminocyclopentane linked α(1a)-receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all stereochemical permutations for their effect on α1-receptor binding. (C) 2000 Published by Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)1917-1920
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number17
DOIs
StatePublished - Sep 4 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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