TY - JOUR
T1 - Preoptic area infusions of morphine disrupt-and naloxone restores parental-like behavior in juvenile rats
AU - Wellman, Jacqueline
AU - Carr, David
AU - Graham, Amanda
AU - Jones, Hendree
AU - Humm, J. Leigh
AU - Ruscio, Michael
AU - Billack, Blase
AU - Kinsley, Craig H.
N1 - Funding Information:
The authors gratefully acknowledge the fine and insightful comments provided by Drs. Kenneth Blick, Robert Bridges, and Frederick Kozub. We would like to thank the National Science Foundation (USE-9250537), the Keck Foundation, the George L. Suhor Foundation, and the University of Richmond Faculty, Graduate and Undergraduate Research Committees for their very generous support during the conduct of this project.
PY - 1997
Y1 - 1997
N2 - As in the adult lactating female, opioids disrupt (and naloxone restores), parental behavior in juvenile rats (~25 days of age). Because the preoptic area regulates the display of parental behavior in lactating females, we examined its parental behavior role in the juvenile rat. At 21 days of age, juvenile rats were implanted with bilateral cannulae aimed at the preoptic area using a modified Kopf stereotaxic and extrapolating from a developing-rat brain atlas [58], and divided into two groups: initiation and maintenance. On day 25, the initiation group received bilateral infusions of either morphine (0.50 μg), saline (0.25 μl), or morphine plus naloxone (0.25 μg). Thirty minutes later, they were exposed to three 1-6-day-old pups; the maintenance group was exposed to pups until they displayed 2 consecutive days of parental behavior, then infused. Morphine disrupted parental behavior in both the Initiation and Maintenance groups, and naloxone restored the behavior to control/saline levels. Parental behavior in the juvenile animal of both sexes, therefore, is under opioid regulation that parallels the adult female.
AB - As in the adult lactating female, opioids disrupt (and naloxone restores), parental behavior in juvenile rats (~25 days of age). Because the preoptic area regulates the display of parental behavior in lactating females, we examined its parental behavior role in the juvenile rat. At 21 days of age, juvenile rats were implanted with bilateral cannulae aimed at the preoptic area using a modified Kopf stereotaxic and extrapolating from a developing-rat brain atlas [58], and divided into two groups: initiation and maintenance. On day 25, the initiation group received bilateral infusions of either morphine (0.50 μg), saline (0.25 μl), or morphine plus naloxone (0.25 μg). Thirty minutes later, they were exposed to three 1-6-day-old pups; the maintenance group was exposed to pups until they displayed 2 consecutive days of parental behavior, then infused. Morphine disrupted parental behavior in both the Initiation and Maintenance groups, and naloxone restored the behavior to control/saline levels. Parental behavior in the juvenile animal of both sexes, therefore, is under opioid regulation that parallels the adult female.
KW - Morphine
KW - Naloxone
KW - Preoptic area infusions
UR - http://www.scopus.com/inward/record.url?scp=0030829094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030829094&partnerID=8YFLogxK
U2 - 10.1016/S0361-9230(97)00111-1
DO - 10.1016/S0361-9230(97)00111-1
M3 - Article
C2 - 9292209
AN - SCOPUS:0030829094
SN - 0361-9230
VL - 44
SP - 183
EP - 191
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 2
ER -