Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.

Timothy R. Kuklo, H. Thomas Temple, Brett D. Owens, John Juliano, Richard B. Islinger, Yvonne Andejeski, Deborah Frassica, B. Hudson Berrey

Research output: Contribution to journalArticle

Abstract

In this article, we report results from a retrospective consecutive series of 117 patients with soft-tissue sarcomas treated with adjuvant radiation and surgical resection at 2 associated institutions. Fifty-nine patients received preoperative radiation; 58 patients received postoperative radiation. Mean clinical follow-ups were 6.1 years and 8.4 years, respectively. Nineteen (32.2%) of 59 patients in the preoperative group and 17 (29.3%) of 58 patients in the postoperative group had wound complications (P = .89). Three (5.1%) of 59 sarcomas in the preoperative group and 7 (12.1%) of 58 sarcomas in the postoperative group recurred locally (P = .19). Improved local disease control and other potential advantages of using preoperative radiation make this a preferred adjuvant treatment.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Volume34
Issue number2
StatePublished - Feb 2005
Externally publishedYes

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Sarcoma
Radiotherapy
Radiation
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Kuklo, T. R., Temple, H. T., Owens, B. D., Juliano, J., Islinger, R. B., Andejeski, Y., ... Berrey, B. H. (2005). Preoperative versus postoperative radiation therapy for soft-tissue sarcomas. American journal of orthopedics (Belle Mead, N.J.), 34(2), 75-80.

Preoperative versus postoperative radiation therapy for soft-tissue sarcomas. / Kuklo, Timothy R.; Temple, H. Thomas; Owens, Brett D.; Juliano, John; Islinger, Richard B.; Andejeski, Yvonne; Frassica, Deborah; Berrey, B. Hudson.

In: American journal of orthopedics (Belle Mead, N.J.), Vol. 34, No. 2, 02.2005, p. 75-80.

Research output: Contribution to journalArticle

Kuklo, TR, Temple, HT, Owens, BD, Juliano, J, Islinger, RB, Andejeski, Y, Frassica, D & Berrey, BH 2005, 'Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.', American journal of orthopedics (Belle Mead, N.J.), vol. 34, no. 2, pp. 75-80.
Kuklo TR, Temple HT, Owens BD, Juliano J, Islinger RB, Andejeski Y et al. Preoperative versus postoperative radiation therapy for soft-tissue sarcomas. American journal of orthopedics (Belle Mead, N.J.). 2005 Feb;34(2):75-80.
Kuklo, Timothy R. ; Temple, H. Thomas ; Owens, Brett D. ; Juliano, John ; Islinger, Richard B. ; Andejeski, Yvonne ; Frassica, Deborah ; Berrey, B. Hudson. / Preoperative versus postoperative radiation therapy for soft-tissue sarcomas. In: American journal of orthopedics (Belle Mead, N.J.). 2005 ; Vol. 34, No. 2. pp. 75-80.
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