Preoperative evaluation of pancreatic masses with positron emission tomography using 18F-fluorodeoxyglucose

Diagnostic limitations

Andreas Sendler, Norbert Avril, Hermann Helmberger, Jens Stollfuß, Wolfgang Weber, Frank Bengel, Markus Schwaiger, Jürgen D. Roder, J. Rüdiger Siewert

Research output: Contribution to journalArticle

Abstract

Identification of pancreatic cancer in patients presenting with an enlarged pancreatic mass is a major diagnostic problem. Positron emission tomography (PET) using the radiolabeled glucose analogue 18F-fluorodeoxyglucose (FDG) has been suggested to provide excellent accuracy for noninvasive determination of suspicious pancreatic masses. We conducted a prospective study to verify these results. Forty-two patients admitted for pancreatic surgery underwent PET scanning. Image analysis was based on visual film evaluation and quantification of regional tracer uptake. PET imaging was visually analyzed by three observers blinded for the results of other diagnostic tests; they qualitatively graded the scans using a five-point scale (I = low to V = high) for the presence and intensity of focal FDG uptake. Diagnosis was proven by histology (n = 38) or follow-up (n = 4). Furthermore, the results of PET were compared with helical computed tomography (CT) and conventional ultrasonography (US), done during the routine diagnostic workup before pancreatic cancer surgery. Regarding only the results with scores of IV and V as positive for representing definite malignancy yielded a sensitivity of 71% and a specificity of 64% for film reading. Quantification of regional tracer uptake contributed no significant diagnostic advantage for differentiation between benign and malignant tumors. Helical CT revealed a sensitivity of 74% and a specificity of 45.5% and abdominal US 56% and 50%, respectively. We concluded that PET imaging provides only fair diagnostic accuracy (69%) for characterizing enlarged pancreatic masses. PET does not allow exclusion of malignant tumors. In doubtful cases, the method must be combined with other imaging modalities, such as helical CT. The results indicate that the number of invasive procedures is not significantly reduced by PET imaging.

Original languageEnglish (US)
Pages (from-to)1121-1129
Number of pages9
JournalWorld Journal of Surgery
Volume24
Issue number9
DOIs
StatePublished - 2000
Externally publishedYes

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Fluorodeoxyglucose F18
Positron-Emission Tomography
Spiral Computed Tomography
Pancreatic Neoplasms
Ultrasonography
Neoplasms
Routine Diagnostic Tests
Reading
Histology
Prospective Studies
Glucose

ASJC Scopus subject areas

  • Surgery

Cite this

Preoperative evaluation of pancreatic masses with positron emission tomography using 18F-fluorodeoxyglucose : Diagnostic limitations. / Sendler, Andreas; Avril, Norbert; Helmberger, Hermann; Stollfuß, Jens; Weber, Wolfgang; Bengel, Frank; Schwaiger, Markus; Roder, Jürgen D.; Siewert, J. Rüdiger.

In: World Journal of Surgery, Vol. 24, No. 9, 2000, p. 1121-1129.

Research output: Contribution to journalArticle

Sendler, A, Avril, N, Helmberger, H, Stollfuß, J, Weber, W, Bengel, F, Schwaiger, M, Roder, JD & Siewert, JR 2000, 'Preoperative evaluation of pancreatic masses with positron emission tomography using 18F-fluorodeoxyglucose: Diagnostic limitations', World Journal of Surgery, vol. 24, no. 9, pp. 1121-1129. https://doi.org/10.1007/s002680010182
Sendler, Andreas ; Avril, Norbert ; Helmberger, Hermann ; Stollfuß, Jens ; Weber, Wolfgang ; Bengel, Frank ; Schwaiger, Markus ; Roder, Jürgen D. ; Siewert, J. Rüdiger. / Preoperative evaluation of pancreatic masses with positron emission tomography using 18F-fluorodeoxyglucose : Diagnostic limitations. In: World Journal of Surgery. 2000 ; Vol. 24, No. 9. pp. 1121-1129.
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